Abstract
Hibiscus sabdariffa, Lippia citriodora, Rosmarinus officinalis and Olea europaea, are rich in bioactive compounds that represent most of the phenolic compounds' families and have exhibited potential benefits in human health. These plants have been used in folk medicine for their potential therapeutic properties in human chronic diseases. Recent evidence leads to postulate that polyphenols may account for such effects. Nevertheless, the compounds or metabolites that are responsible for reaching the molecular targets are unknown. data based on studies directly using complex extracts on cellular models, without considering metabolic aspects, have limited applicability. In contrast, studies exploring the absorption process, metabolites in the blood circulation and tissues have become essential to identify the intracellular final effectors that are responsible for extracts bioactivity. Once the cellular metabolites are identified using high-resolution mass spectrometry, docking techniques suppose a unique tool for virtually screening a large number of compounds on selected targets in order to elucidate their potential mechanisms. we provide an updated overview of the in vitro and in vivo studies on the toxicity, absorption, permeabi...Continue Reading
Citations
Jun 5, 2018·Food & Function·Marina Boix-CastejónVicente Micol
Mar 1, 2019·Scientific Reports·María Herranz-LópezVicente Micol
Aug 2, 2019·Rejuvenation Research·Tullia MaraldiCristina Angeloni
Jan 16, 2020·Foods·Javier MarhuendaJavier López-Román
Feb 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristina ZaragozáMelchor Álvarez-Mon
May 12, 2020·Journal of Food Biochemistry·Javier VioqueManuel Alaiz
Oct 9, 2018·Current Medicinal Chemistry·Francisco Javier Álvarez-MartínezVicente Micol
Oct 3, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yusni Yusni, Firdalena Meutia
Sep 27, 2018·International Journal of Molecular Sciences·Ganapathy SivakumarLuigi Gentile
Apr 19, 2019·International Journal of Molecular Sciences·Justine Renaud, Maria-Grazia Martinoli
Jul 3, 2019·Frontiers in Plant Science·Riadh IlahyMarcello Salvatore Lenucci
Mar 22, 2020·Biomedicines·Enrico Sangiovanni, Mario Dell'Agli
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·María Del Carmen Villegas-AguilarAntonio Segura-Carretero
Jan 2, 2019·Medicines·María Herranz-LópezEnrique Barrajón-Catalán
Jan 6, 2021·Biology·Wenli SunJianxin Shi
Dec 17, 2018·European Journal of Medicinal Chemistry·Haiwei LiSulong Xiao
Mar 29, 2020·Food & Function·Santa CirmiMichele Navarra
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Javier MarhuendaFrancisco Javier López-Román
Jul 7, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Cristina ZaragozáMelchor Álvarez-Mon
Aug 2, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·María Herranz-LópezVicente Micol
Aug 28, 2021·Foods·Maria Assunta CrescenziPaola Montoro