Plant-derived vaccines: an approach for affordable vaccines against cervical cancer

Human Vaccines & Immunotherapeutics
Mohammad T WaheedAndreas G Lössl

Abstract

Several types of human papillomavirus (HPV) are causatively associated with cervical cancer, which is the second most common cancer in women worldwide. HPV-16 and 18 are among the high risk types and responsible for HPV infection in more than 70% of the cases. The majority of cervical cancer cases occur in developing countries. Currently available HPV vaccines are expensive and probably unaffordable for most women in low and middle income countries. Therefore, there is a need to develop cost-effective vaccines for these countries. Due to many advantages, plants offer an attractive platform for the development of affordable vaccines. These include low cost of production, scalability, low health risks and the potential ability to be used as unprocessed or partially processed material. Among several techniques, chloroplast transformation is of eminent interest for the production of vaccines because of high yield of foreign protein and lack of transgene transmission through pollen. In this commentary, we focus on the most relevant aspects of plant-derived vaccines that are decisive for the future development of cost-effective HPV vaccines.

References

Jun 5, 2002·Nature Reviews. Cancer·Harald zur Hausen
Aug 14, 2003·Journal of Virology·Sophia BiemeltMartin Müller
Mar 9, 2004·Current Opinion in Plant Biology·Rainer FischerRichard M Twyman
Mar 10, 2005·Acta Biochimica Et Biophysica Sinica·Hong-Li LiuLü-Sheng Si
Jul 5, 2005·EMBO Reports·Julian K-C MaUNKNOWN European Union Framework 6 Pharma-Planta Consortium
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Farin KamangarWilliam F Anderson
Sep 5, 2006·Vaccine·D Maxwell Parkin, Freddie Bray
Apr 4, 2007·International Journal of Cancer. Journal International Du Cancer·Jennifer S SmithGary M Clifford
Jul 14, 2007·Disease Markers·Martin Müller, Lutz Gissmann
Oct 23, 2008·The Plant Journal : for Cell and Molecular Biology·Melanie OeyRalph Bock
Apr 10, 2009·Biotechnology Advances·Siddharth TiwariRakesh Tuli
May 12, 2009·Human Vaccines·Abdoreza Davoodi-SemiromiHenry Daniell
Oct 20, 2009·Trends in Plant Science·Henry DaniellStephen J Streatfield
Dec 10, 2009·Journal of Biotechnology·Imke A J DreesenMartin Fussenegger
Mar 9, 2010·Trends in Biotechnology·Ralph Bock, Heribert Warzecha
Aug 3, 2010·Expert Review of Vaccines·Colomba GiorgiEdward P Rybicki
Jan 18, 2011·Plant Physiology·Pal Maliga, Ralph Bock
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Mar 2, 2011·Human Vaccines·Edward P RybickiInga I Hitzeroth
Mar 31, 2011·Plant Biotechnology Journal·Andreas G Lössl, Mohammad T Waheed

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Citations

Feb 4, 2016·SpringerPlus·Mohammad Tahir WaheedAndreas Günter Lössl
Oct 19, 2014·Biotechnology Letters·Shah FahadJianliang Huang
Dec 22, 2012·Immunotherapy·Andreas G Lössl, Jihong L Clarke
Feb 20, 2019·American Journal of Men's Health·Judy Yuen-Man SiuLeo Ho-Man Leung
Jul 17, 2013·Biotechnology Journal·Kathleen Hefferon
Sep 22, 2015·Plant Biotechnology Journal·Hui-Ting Chan, Henry Daniell
Sep 9, 2017·Future Science OA·Kathleen Hefferon
Sep 29, 2020·Journal of Family Medicine and Primary Care·Kabiru A RabiuOluwarotimi Ireti Akinola
Aug 7, 2021·Vaccines·Srividhya VenkataramanMounir Abouhaidar
Nov 28, 2021·Biotechnology Letters·Farshad HemmatiAlireza Afsharifar

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