Plant Mitochondrial Inner Membrane Protein Insertion

International Journal of Molecular Sciences
Renuka KolliChris Carrie

Abstract

During the biogenesis of the mitochondrial inner membrane, most nuclear-encoded inner membrane proteins are laterally released into the membrane by the TIM23 and the TIM22 machinery during their import into mitochondria. A subset of nuclear-encoded mitochondrial inner membrane proteins and all the mitochondrial-encoded inner membrane proteins use the Oxa machinery-which is evolutionarily conserved from the endosymbiotic bacterial ancestor of mitochondria-for membrane insertion. Compared to the mitochondria from other eukaryotes, plant mitochondria have several unique features, such as a larger genome and a branched electron transport pathway, and are also involved in additional cellular functions such as photorespiration and stress perception. This review focuses on the unique aspects of plant mitochondrial inner membrane protein insertion machinery, which differs from that in yeast and humans, and includes a case study on the biogenesis of Cox2 in yeast, humans, two plant species, and an algal species to highlight lineage-specific similarities and differences. Interestingly, unlike mitochondria of other eukaryotes but similar to bacteria and chloroplasts, plant mitochondria appear to use the Tat machinery for membrane insertio...Continue Reading

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Citations

Sep 13, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Anne KönnelKatrin Philippar
Jun 30, 2019·The Journal of Pharmacology and Experimental Therapeutics·Angela SaccoPaola Patrignani
Dec 6, 2018·International Journal of Molecular Sciences·Nicolas L Taylor
Mar 2, 2019·Annual Review of Plant Biology·Etienne H MeyerChris Carrie
Jul 19, 2018·The Biochemical Journal·Abi S GhifariMonika W Murcha
Jan 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Mor HananyDror Sharon
Nov 6, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shawna K BrookensMark R Boothby
Feb 13, 2021·Neurology. Genetics·Kathleen E LangbehnPeggy C Nopoulos
Jan 2, 2021·The Journal of Pharmacology and Experimental Therapeutics·Scott D BarnettIain L O Buxton
Apr 11, 2021·Molecular Biology and Evolution·Jan PyrihJulius Lukeš
Apr 22, 2021·Cancer Discovery·Amy C MandigoKaren E Knudsen
Sep 17, 2021·The Plant Journal : for Cell and Molecular Biology·Ian Max MøllerOlivier Van Aken
Aug 13, 2021·Molecular Cancer Research : MCR·Andrew DelaCourtAnand S Mehta
Oct 9, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lauren E BarberJulie R Palmer

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Methods Mentioned

BETA
protein folding
X-ray

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