Abstract
The glycosylated phenylpropanoid verbascoside isolated from cultured cells of the medicinal plant Syringa vulgaris (Oleaceae) has previously been characterized as an effective scavenger of biologically active free radicals such as hydroxyl, superoxide, and nitric oxide, as a chelator of redox active transition metal ions (Fe (2+), Fe (3+), Cu (2+), and Ni (2+)), and an inhibitor of lipid peroxidation. In the present work, we have compared the cytoprotective effects of the biotechnologically produced verbascoside with two commercially available polyphenols (the glycosylated flavonoid rutin and its aglycone quercetin) against free radical-mediated UVC-induced cellular death in cultures of human keratinocytes (HaCaT) and breast cancer cells (MCF 7). We have shown that all the polyphenols studied afforded effective protection against UVC-induced necrosis and did not prevent UVC-induced apoptosis in both normal and tumor cell lines. The cytoprotection did not correlate either with UVC absorbance by polyphenols or with their superoxide radical scavenging properties. However, UVC protection strongly depended on the lipid peroxidation inhibiting and Fe (2+) chelating properties of polyphenols. We suggest that these plant polyphenols co...Continue Reading
Citations
May 29, 2013·Chemico-biological Interactions·Yun Jeong KimChung Soo Lee
Feb 18, 2016·Journal of Plant Research·Flora PensecJulie Chong
Sep 10, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guillaume MartiKatia Gindro
May 31, 2011·Journal of Dermatological Science·Saveria PastoreLiudmila G Korkina
Oct 25, 2012·Mediators of Inflammation·Lulli DanielaKorkina Liudmila
Jan 14, 2009·Phytotherapy Research : PTR·Dae Won KimMoo-Ho Won
Apr 19, 2012·Mycoses·O SchumppK Gindro
Oct 26, 2011·International Journal of Cosmetic Science·G Dell'Acqua, K Schweikert
Sep 5, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Rossella CalòLaura Marabini
Jul 23, 2014·Biotechnology Advances·Kalina AlipievaMilen I Georgiev
May 21, 2013·International Immunopharmacology·Chung Soo LeeMin Won Lee
Dec 27, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Luis Felipe Santos-CruzMaría Eugenia Heres-Pulido
Jan 15, 2011·Journal of Biomedicine & Biotechnology·Xin LiuLishe Gan
May 20, 2011·Biomacromolecules·Ngoc Quyen TranKi Dong Park
May 13, 2017·Biomolecules·Liudmila G KorkinaChiara de Luca
Aug 18, 2020·Journal of Clinical Biochemistry and Nutrition·Hisae OkuKyoko Ishiguro
Feb 13, 2021·Plants·Milton Abraham Gómez-HernándezMaría Elena Estrada-Zúñiga
Mar 11, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M Espinosa-GonzálezJ G Avila-Acevedo
Aug 28, 2021·Antioxidants·Aimilia D SklirouAlexios Leandros Skaltsounis
Nov 11, 2020·Mini Reviews in Medicinal Chemistry·Fatemeh FarjadmandMina Saeedi