Plant-specific CC-type glutaredoxins: functions in developmental processes and stress responses

Biological Chemistry
Nora GutscheChristiane Gatz

Abstract

Glutaredoxins (GRXs) are small oxidoreductases of the thioredoxin family proteins that can either regulate the thiol redox state of proteins or are linked to iron metabolism because of their ability to incorporate iron-sulfur [2Fe-2S] clusters. Here we review recent research on a land plant-specific class of GRX-like proteins, which are characterized by the conserved CC motif in the active centre. Loss-of-function mutants of CC-type GRXs in Arabidopsis (also named ROXYs), maize, and rice have unraveled a role in floral development, including regulation of organ primordia initiation, control of organ identity gene expression, and progression into meiosis in the male germ line. Other CC-type GRXs play a role in stress responses, most likely through their capacity to regulate nuclear gene expression. Consistently, CC-type GRXs, physically and genetically interact with individual members of the TGA transcription factor family. One of the challenges in the future is to unravel whether ROXYs control the redox state of TGA factors or other yet unknown target proteins or whether they regulate gene expression through other processes. Other intriguing questions concern the original function of the first CC-type GRXs in basal land plants ...Continue Reading

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Citations

Dec 4, 2015·International Journal of Molecular Sciences·Olga Pechanova, Tibor Pechan
Apr 10, 2015·Biological Chemistry·Johannes M HerrmannTobias P Dick
Apr 5, 2017·Nature Communications·Patricia BegasMarcel Deponte
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Aug 11, 2018·Development·Amna Mhamdi, Frank Van Breusegem
Aug 23, 2019·The Plant Journal : for Cell and Molecular Biology·Fan XuChengcai Chu
Oct 14, 2020·Metallomics : Integrated Biometal Science·Gretchen Elizabeth Kroh, Marinus Pilon
Dec 29, 2020·Trends in Plant Science·Pierre GautratSandrine Ruffel
Feb 22, 2021·Journal of Biotechnology·Pankaj Kumar VermaDebasis Chakrabarty
Apr 2, 2021·Plant Physiology·Rashmi SasidharanRomy R Schmidt

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Methods Mentioned

BETA
two hybrid
transgenic
immunoprecipitation
ChIP
X-ray
NMR

Software Mentioned

MODELLER
MacVector
ClustalW
UCSF Chimera

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