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Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer's disease

Scientific Reports

Nov 14, 2019

Kohei YuyamaYasuyuki Igarashi

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Abstract

The accumulation of amyloid-β protein (Aβ) in brain is linked to the early pathogenesis of Alzheimer's disease (AD). We previously reported that neuron-derived exosomes promote Aβ clearance in the brains of amyloid precursor protein transgenic mice and that exosome production is modulat...read more

Mentioned in this Paper

Alzheimer's Disease
Brain
Ceramides
Cognition
Glucosylceramides
Metabolism
Laboratory mice
Mice, Transgenic
Neurons
Pathologic Processes
4
1
1
8
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Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer's disease

Scientific Reports

Nov 14, 2019

Kohei YuyamaYasuyuki Igarashi

PMID: 31727994

DOI: 10.1038/s41598-019-53394-w

Abstract

The accumulation of amyloid-β protein (Aβ) in brain is linked to the early pathogenesis of Alzheimer's disease (AD). We previously reported that neuron-derived exosomes promote Aβ clearance in the brains of amyloid precursor protein transgenic mice and that exosome production is modulat...read more

Mentioned in this Paper

Alzheimer's Disease
Brain
Ceramides
Cognition
Glucosylceramides
4
1
1
8

Similar Papers Found In These Feeds

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Paper Details
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