Plant stem cell maintenance by transcriptional cross-regulation of related receptor kinases

Development
Zachary L NimchukE M Meyerowitz

Abstract

The CLAVATA3 (CLV3)-CLAVATA1 (CLV1) ligand-receptor kinase pair negatively regulates shoot stem cell proliferation in plants. clv1 null mutants are weaker in phenotype than clv3 mutants, but the clv1 null phenotype is enhanced by mutations in the related receptor kinases BARELY ANY MERISTEM 1, 2 and 3 (BAM1, 2 and 3). The basis of this genetic redundancy is unknown. Here, we demonstrate that the apparent redundancy in the CLV1 clade is in fact due to the transcriptional repression of BAM genes by CLV1 signaling. CLV1 signaling in the rib meristem (RM) of the shoot apical meristem is necessary and sufficient for stem cell regulation. CLV3-CLV1 signaling in the RM represses BAM expression in wild-type Arabidopsis plants. In clv1 mutants, ectopic BAM expression in the RM partially complements the loss of CLV1. BAM regulation by CLV1 is distinct from CLV1 regulation of WUSCHEL, a proposed CLV1 target gene. In addition, quadruple receptor mutants are stronger in phenotype than clv3, pointing to the existence of additional CLV1/BAM ligands. These data provide an explanation for the genetic redundancy seen in the CLV1 clade and reveal a novel feedback operating in the control of plant stem cells.

References

Mar 9, 1999·The Plant Journal : for Cell and Molecular Biology·S J Clough, A F Bent
Nov 26, 1999·The Plant Journal : for Cell and Molecular Biology·A SessionsM F Yanofsky
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·S R CutlerC R Somerville
Jun 18, 2002·Plant Physiology·Ulrike BrandRüdiger Simon
Dec 22, 2005·The Plant Journal : for Cell and Molecular Biology·Brody J DeYoungSteven E Clark
Apr 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ji-Young LeePhilip N Benfey
Aug 12, 2006·Science·Tatsuhiko KondoYouji Sakagami
Sep 5, 2006·Trends in Plant Science·Georgette C BriggsChristian S Hardtke
Dec 29, 2006·BioTechniques·Philippa J Barrell, Anthony J Conner
Nov 3, 2007·Science·Siobhan M BradyPhilip N Benfey
Jan 19, 2008·Science·Mari OgawaYoshikatsu Matsubayashi
Feb 11, 2009·Cell·Ran KafriYitzhak Pilpel
Jun 16, 2009·Nature Chemical Biology·Kentaro OhyamaYoshikatsu Matsubayashi
Sep 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sean P GordonElliot M Meyerowitz
May 25, 2010·Developmental Cell·Wolfgang BuschJan U Lohmann
Jul 16, 2010·The Plant Journal : for Cell and Molecular Biology·Yongfeng GuoSteven E Clark
Oct 28, 2010·Development·Atsuko KinoshitaShinichiro Sawa
Feb 22, 2011·Current Biology : CB·Zachary L NimchukElliot M Meyerowitz
Jul 5, 2011·Genes & Development·Saiko YoshidaCris Kuhlemeier
Feb 11, 2012·The Plant Journal : for Cell and Molecular Biology·Hidefumi ShinoharaYoshikatsu Matsubayashi
Feb 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Vijay S ChickarmaneElliot M Meyerowitz
Apr 4, 2013·Molecular Systems Biology·Ram Kishor YadavG Venugopala Reddy
Apr 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Stephen DepuydtChristian S Hardtke

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Citations

Jan 25, 2016·Current Opinion in Plant Biology·Cara L SoyarsZachary L Nimchuk
Mar 21, 2016·Plant Molecular Biology·Takao ArayaHideki Takahashi
Jun 7, 2015·Journal of Experimental Botany·Jisheng ChenZhenbiao Yang
May 26, 2015·Nature Genetics·Cao XuZachary B Lippman
May 1, 2016·Trends in Genetics : TIG·Mary Galli, Andrea Gallavotti
May 28, 2016·Journal of Experimental Botany·Yasuka L YamaguchiShinichiro Sawa
Jun 25, 2016·Journal of Experimental Botany·Ora Hazak, Christian S Hardtke
Jul 10, 2016·BMC Biology·Maike Breiden, Rüdiger Simon
Feb 18, 2017·International Journal of Molecular Sciences·Annu Smitha NinanPaula E Jameson
Mar 28, 2018·Nature Plants·Fang Xu, David Jackson
Oct 24, 2017·ELife·Christophe GaillochetJan U Lohmann
Sep 15, 2016·Development·Marc SomssichDavid Jackson
Feb 13, 2019·Journal of Experimental Botany·Grace L ChongloiUsha Vijayraghavan
May 12, 2019·Development·Arun SampathkumarElliot M Meyerowitz
Jan 29, 2020·The New Phytologist·Jarrett ManMadelaine Bartlett
Aug 9, 2019·Plant & Cell Physiology·Munenori KitagawaDavid Jackson
Dec 14, 2018·Cellular and Molecular Life Sciences : CMLS·Naoyuki Uchida, Keiko U Torii
Aug 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sayan ChakrabortyGuozhou Xu
Apr 26, 2020·Journal of Plant Research·Joseph Cammarata, Michael J Scanlon
Apr 17, 2019·Nature Genetics·Daniel Rodriguez-LealZachary B Lippman
May 3, 2019·Nature Genetics·Elizabeth A Kellogg
May 1, 2019·Annual Review of Plant Biology·Munenori Kitagawa, David Jackson
Dec 9, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ashley D CrookZachary L Nimchuk
Nov 7, 2020·Current Biology : CB·Daniel S JonesZachary L Nimchuk
Dec 18, 2020·Journal of Experimental Botany·Filipa Lara LopesBenoit Landrein
Mar 5, 2021·Frontiers in Plant Science·Chuanmei ZhuElizabeth A Kellogg
May 14, 2020·Trends in Plant Science·Jennifer C Fletcher
Oct 12, 2017·Seminars in Cell & Developmental Biology·Peter Bommert, Clinton Whipple
Jul 8, 2019·Current Opinion in Plant Biology·Joseph CammarataMichael J Scanlon
May 21, 2018·Current Opinion in Plant Biology·Qingyu WuDavid Jackson

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