Plant sterol-enriched fermented milk enhances the attainment of LDL-cholesterol goal in hypercholesterolemic subjects

European Journal of Nutrition
Nuria PlanaDANACOL group

Abstract

The number of hypercholesterolemic individuals who do not meet their cholesterol recommended targets is inappropriately high. The use of plant sterol-enriched foods could help in this clinical setting. To evaluate the efficacy and side effects of plant sterol-enriched fermented milk in reducing LDL-cholesterol and increasing the number of patients who attain their therapeutic targets. This was a multicentre, randomised, double-blind, placebo-controlled, parallel clinical trial. Eighty-three hypercholesterolemic patients that were not at therapeutic goals were studied. The patients received one 100 ml serving of either plain (control) low-fat or phytosterol enriched (1.6 g of free sterol equivalents) drinkable yogurt per day along with the main meal for 42 days. The principal variables were variation on LDL cholesterol (LDL-C) concentration and the number of patients achieving therapeutic goals after intervention. Patients on phytosterols attained an average LDL-C reduction of more than 10% (12.2% after 3 weeks; 10.6% after 6 weeks) (P = 0.001; 95% CI: 4.03-19.00) regardless of statin therapy compared to the control group. About 50% of the subjects on phytosterols, as compared to 20% of controls, attained their LDL-C target valu...Continue Reading

References

May 29, 1987·The American Journal of Cardiology·P W WilsonW B Kannel
Oct 1, 1996·Journal of Epidemiology and Community Health·M Woodward
Nov 26, 1999·The Journal of Nutrition·T T Nguyen
Mar 24, 2000·BMJ : British Medical Journal·M Law
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Feb 15, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Alice H Lichtenstein
Feb 27, 2004·European Journal of Clinical Nutrition·P M CliftonP Nestel
May 28, 2004·European Journal of Clinical Nutrition·A B ThomsenA Berger
Aug 28, 2004·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·F H O'NeillG R Thompson
Oct 30, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Kenneth R WilundHelen H Hobbs
Nov 9, 2004·Atherosclerosis. Supplements·T R PedersenUNKNOWN Scandinavian Simvastatin Survival Study Group
Jan 27, 2005·PharmacoEconomics·F J García RuizUNKNOWN REALITY Study Group
Mar 16, 2005·Revista clínica española·J Algorta PinedaS Francisco Terreros
Apr 1, 2005·Medicina clínica·Luis A Alvarez-SalaUNKNOWN Grupo PREVENCAT
Nov 16, 2005·Journal of the American College of Cardiology·Jennifer G RobinsonHelmut Schrott
Jan 13, 2006·European Journal of Clinical Nutrition·R KorpelaM J Tikkanen
Jan 31, 2006·The American Journal of Cardiology·Anne C GoldbergCurtis A Spilburg
Mar 9, 2006·Journal of the American College of Nutrition·Kgomotso G MoruisiAnna M Opperman
Jul 5, 2006·Annals of Internal Medicine·Ramon EstruchUNKNOWN PREDIMED Study Investigators
Jan 18, 2007·European Journal of Nutrition·Leena SeppoRiitta Korpela

❮ Previous
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Citations

Mar 9, 2012·Canadian Journal of Dietetic Practice and Research : a Publication of Dietitians of Canada = Revue Canadienne De La Pratique Et De La Recherche En Diététique : Une Publication Des Diététistes Du Canada·Todd C RideoutAtif B Awad
Oct 30, 2009·International Journal of Molecular Sciences·Carla M SáCristina Pereira-Wilson
Jan 13, 2015·Nutrients·Stephanie N ChiltonGregor Reid
Feb 15, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·T E SialveraA Zampelas
Apr 23, 2014·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·F PaillardE van Ganse
Mar 20, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mitchell L JonesSatya Prakash
Mar 5, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Christos S DerdemezisMoses S Elisaf
Oct 14, 2008·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Victoria Shanta RetelnyJulie L Roth
Mar 9, 2018·Current Opinion in Lipidology·Kirstin Mittelstraß, Melanie Waldenberger
Dec 19, 2008·The Journal of Nutrition·Isabelle DemontyElke A Trautwein
Aug 14, 2018·Nutrition Reviews·Peter J H JonesOliver Weingärtner
Jul 10, 2018·Current Medicinal Chemistry·Montserrat Cofán, Emilio Ros
Feb 2, 2021·Frontiers in Pharmacology·Bahare SalehiWojciech Koch
Jul 31, 2021·World Journal of Microbiology & Biotechnology·Aida AitzhanovaAmankeldy Sadanov

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