PMID: 9539701May 16, 1998Paper

Plant terpenoid synthases: molecular biology and phylogenetic analysis

Proceedings of the National Academy of Sciences of the United States of America
J BohlmannR Croteau

Abstract

This review focuses on the monoterpene, sesquiterpene, and diterpene synthases of plant origin that use the corresponding C10, C15, and C20 prenyl diphosphates as substrates to generate the enormous diversity of carbon skeletons characteristic of the terpenoid family of natural products. A description of the enzymology and mechanism of terpenoid cyclization is followed by a discussion of molecular cloning and heterologous expression of terpenoid synthases. Sequence relatedness and phylogenetic reconstruction, based on 33 members of the Tps gene family, are delineated, and comparison of important structural features of these enzymes is provided. The review concludes with an overview of the organization and regulation of terpenoid metabolism, and of the biotechnological applications of terpenoid synthase genes.

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Citations

Dec 18, 2001·Biotechnology and Bioengineering·V J MartinJ D Keasling
Nov 24, 1999·Archives of Biochemistry and Biophysics·J W JiaX Y Chen
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Jul 16, 1999·Insect Biochemistry and Molecular Biology·J A TillmanG J Blomquist

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