Plant Viruses as Nanoparticle-Based Vaccines and Adjuvants

Vaccines
Marie-Ève LebelAlain Lamarre

Abstract

Vaccines are considered one of the greatest medical achievements in the battle against infectious diseases. However, the intractability of various diseases such as hepatitis C, HIV/AIDS, malaria, tuberculosis, and cancer poses persistent hurdles given that traditional vaccine-development methods have proven to be ineffective; as such, these challenges have driven the emergence of novel vaccine design approaches. In this regard, much effort has been put into the development of new safe adjuvants and vaccine platforms. Of particular interest, the utilization of plant virus-like nanoparticles and recombinant plant viruses has gained increasing significance as an effective tool in the development of novel vaccines against infectious diseases and cancer. The present review summarizes recent advances in the use of plant viruses as nanoparticle-based vaccines and adjuvants and their mechanism of action. Harnessing plant-virus immunogenic properties will enable the design of novel, safe, and efficacious prophylactic and therapeutic vaccines against disease.

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Citations

Feb 19, 2016·Nano Letters·Marie-Ève LebelAlain Lamarre
Dec 5, 2015·Frontiers in Plant Science·Chiara LicoSelene Baschieri
Aug 24, 2016·Molecular Pharmaceutics·Chintan H KapadiaJoseph M DeSimone
Mar 28, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Gueven EdgueMarkus Sack
Feb 15, 2018·Vaccines·Kathleen L Hefferon
Nov 20, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie-Ève LebelAlain Lamarre
Apr 7, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Mehdi ShahgolzariSteven Fiering
Jul 20, 2017·Journal of Nanobiotechnology·Ariane ThérienDenis Leclerc
Sep 9, 2017·Future Science OA·Kathleen Hefferon
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Apr 28, 2019·Journal for Immunotherapy of Cancer·Mona O MohsenMartin F Bachmann
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Methods Mentioned

BETA
genetic modifications
transgenic
chemical treatment

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