Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal

Antioxidants
Hack Sun ChoiDong-Sun Lee

Abstract

Cancer stem cells (CSCs) are undifferentiated cells that give rise to tumor and resistance to chemotherapy. This study reports that phenylacetaldehyde (PAA), a flower flavor, inhibits formation on breast CSCs. PAA showed anti-proliferation and increased apoptosis of breast cancer. PAA also reduced tumor growth in an in vivo mice model. PAA reduced the CD44+/CD24- and ALDH1-expressing cells, mammosphere formation, and CSC marker genes. PAA preferentially induced reactive oxygen species (ROS) production and combined treatment with PAA and N-acetyl cysteine (NAC) decreased inhibition of mammosphere formation. PAA reduced phosphorylation of nuclear Stat3. PAA inhibited Stat3 signaling through de-phosphorylation of Stat3 and reduced secretory IL-6. Our results suggest that the PAA-induced ROS deregulated Stat3/IL-6 pathway and PAA may be a potential agent targeting breast cancer and CSCs.

References

Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
Feb 14, 2006·Science·Stephen A Goff, Harry J Klee
May 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Denise TiemanHarry J Klee
Oct 26, 2006·Breast Cancer Research : BCR·Carol SheridanHarikrishna Nakshatri
Dec 7, 2007·The Journal of Clinical Investigation·Pasquale SansoneMassimiliano Bonafè
Feb 9, 2010·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Matthew L ClarkeJeeseong Hwang
May 14, 2010·Current Biology : CB·Ian T Baldwin
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dimitrios IliopoulosKevin Struhl
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Jun 21, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hasan KorkayaMax S Wicha
Feb 10, 2012·Antioxidants & Redox Signaling·Xiaoke ShiJingxuan Pan
Aug 14, 2012·Biochemical and Biophysical Research Communications·Yelena GlinkaGérald J Prud'homme
Jan 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Heather A HirschKevin Struhl
Jan 12, 2013·Planta medica·Jullyana de S S QuintansDaniel P Bezerra
Feb 2, 2013·Clinical and Translational Medicine·Lissa Nurrul Abdullah, Edward Kai-Hua Chow
Mar 28, 2013·Breast Cancer Research and Treatment·Christine DethlefsenPernille Hojman
Jun 30, 2014·Advances in Cancer Research·Daohong ZhouDouglas R Spitz
Nov 16, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gideon St HelenNeal L Benowitz
Feb 11, 2015·Experimental and Molecular Pathology·Farhadul IslamAlfred K-Y Lam
Nov 13, 2015·International Journal of Cancer. Journal International Du Cancer·Kasturi Banerjee, Haluk Resat
Sep 10, 2016·Medicine·William H Matsui
Dec 27, 2016·Journal of Cellular Physiology·Mohammad Reza AbbaszadeganMehran Gholamin
Feb 24, 2017·Cell Reports·Haiquan LuGregg L Semenza
Mar 16, 2017·Cancer Cell International·Hack Sun ChoiDuk-Hee Kang
Mar 31, 2017·Anti-cancer Agents in Medicinal Chemistry·Manobjyoti BordoloiBardwi Narzary
Nov 29, 2017·Journal of Clinical Pathology·Bede van SchaijikTinte Itinteang
Apr 26, 2019·Oxidative Medicine and Cellular Longevity·Su-Lim KimDong-Sun Lee

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Methods Mentioned

BETA
xenograft
ELISA
Assay
FACS
transfection
nuclear translocation

Software Mentioned

NICE
GraphPad Prism

Related Concepts

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