Plantar mechanical stimulation attenuates protein synthesis decline in disused skeletal muscle via modulation of nitric oxide level.

Scientific Reports
Sergey A TyganovBoris S Shenkman

Abstract

Both research conducted under microgravity conditions and ground-based space analog studies have shown that air pump-based plantar mechanical stimulation (PMS) of cutaneous mechanoreceptors of the sole of the foot is able to increase neuromuscular activity in the musculature of the lower limbs. This type of stimulation is able to attenuate unloading-induced skeletal muscle atrophy and impaired muscle function. The aim of the present study was to evaluate the effects of PMS on anabolic signaling pathways in rat soleus muscle following 7-day hindlimb suspension (HS) and to elucidate if the effects of PMS on anabolic processes would be NO-dependent. The soles of the feet were stimulated with a frequency of 1-s inflation/1-s deflation with a total of 20 min followed by 10 min rest. This cycle was repeated for 4 h each day. We observed a decrease in the soleus muscle mass after 7-day HS, which was not prevented by PMS. We also observed a decrease in slow-type fiber cross-sectional area (CSA) by 56%, which significantly exceeded a decrease (-22%) in fast-type fiber CSA. PMS prevented a reduction in slow-twitch fiber CSA, but had no effect on fast-twitch fiber CSA. PMS prevented a 63% decrease in protein synthesis after 7-day HS as we...Continue Reading

References

Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J R Lancaster, J B Hibbs
Jan 1, 1990·Journal of Applied Physiology·D B Thomason, F W Booth
May 1, 1990·Hypertension·S M GardinerS Moncada
Aug 1, 1996·Medicine and Science in Sports and Exercise·K M Baldwin
Feb 12, 1998·European Journal of Applied Physiology and Occupational Physiology·F CanonC Y Guezennec
Aug 5, 1998·The American Journal of Physiology·J G TidballM Wehling
Sep 4, 1998·Science·T C HeK W Kinzler
Jul 20, 1999·Journal of Applied Physiology·M Falempin, S F In-Albon
Aug 5, 2000·Journal of Applied Physiology·R H FittsJ J Widrick
Aug 15, 2001·Current Opinion in Neurobiology·K O Johnson
Sep 22, 2001·Hypertension·V A PeottaS S Meyrelles
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 16, 2002·Journal of Applied Physiology·Emily R Morey-Holton, Ruth K Globus
Jun 19, 2002·European Journal of Applied Physiology·Tatiana L Nemirovskaya, Boris S Shenkman
Aug 13, 2002·Advances in Experimental Medicine and Biology·J Timothy InglisRomeo Chua
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Thomas C VaryScot R Kimball
Nov 9, 2002·European Journal of Biochemistry·Gareth J Browne, Christopher G Proud
Jun 8, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jana RudnickDieter Blottner
Feb 22, 2005·Nature Cell Biology·Azadeh ArabiAnthony P H Wright
May 13, 2005·American Journal of Physiology. Cell Physiology·Dustin D Armstrong, Karyn A Esser
Sep 20, 2005·The Journal of Experimental Biology·John A HodgsonV Reggie Edgerton
May 6, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Donald E Ingber
Feb 17, 2007·American Journal of Physical Medicine & Rehabilitation·Katharine Emily Forth, Charles Shannon Layne
Feb 15, 2008·American Journal of Physiology. Cell Physiology·Jason A DrenningDavid S Criswell
Aug 23, 2008·Aviation, Space, and Environmental Medicine·Charles S Layne, Katharine E Forth
Sep 13, 2008·Aviation, Space, and Environmental Medicine·Katharine E Forth, Charles S Layne
Mar 24, 2009·Nature Methods·Enrico K SchmidtPhilippe Pierre
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Denis DryginIngrid Grummt
Jan 1, 2009·Progress in Molecular Biology and Translational Science·Sarah J MahoneyJohn Blenis
Jun 26, 2010·The Journal of Biological Chemistry·Scot R Kimball, Leonard S Jefferson
Oct 21, 2010·Doklady. Biochemistry and Biophysics·E A LysenkoB S Shenkman
Dec 15, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Craig A GoodmanTroy A Hornberger
Mar 5, 2011·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·I V OgnevaI B Kozlovskaya
Mar 12, 2011·Cell Biochemistry and Function·Gautam KaulTowseef Rafeequi
May 31, 2011·The International Journal of Biochemistry & Cell Biology·Troy A Hornberger
Jun 7, 2011·Biochemistry. Biokhimii︠a︡·Yu N LomonosovaT L Nemirovskaya

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Sep 28, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sergey A TyganovBoris S Shenkman

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