Plaque and deposits in nine human stone diseases.

Urological Research
Fredric L CoeElaine M Worcester

Abstract

Data concerning nine forms of human stone disease, along with observations on normal people give new insights into formation of interstitial apatite plaque and intra-tubular crystal deposits. In general, across multiple disease states, one can reproduce the same relationships between plaque abundance as is seen among patients within individual disease states, so that the link between plaque and high urine calcium excretion, and low urine volume and pH seems increasingly secure. From this, one can propose a specific model of plaque formation, susceptible to experimental test. In many diseases, formation of inner medullary collecting duct and Bellini duct deposits is compatible with simple crystallization driven by urine supersaturations; this is expected in that these segments contain tubule fluid quite close in composition to final urine. But in ileostomy, small bowel disease and obesity bypass patients, crystals found in deposits are not those expected: apatite and urates in deposits, despite formation of highly acidic urine. Also, this discrepancy suggests the possibility of divergence between bulk urine pH and pH of focal collecting ducts, a new kind of possibility that is susceptible to experimental test.

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Citations

Oct 23, 2010·Urological Research·Brian R MatlagaBruce J Trock
Aug 22, 2013·Urolithiasis·Hans-Göran Tiselius
May 15, 2013·Journal of Endourology·Alexandru CiudinAntonio Alcaraz
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Nov 28, 2012·The Urologic Clinics of North America·Herman Singh BaggaMarshall L Stoller
Nov 20, 2012·The Journal of Urology·James E Lingeman
Jan 24, 2012·The Journal of Urology·Saeed R KhanManoj Monga
Jan 31, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Andrew P EvanFredric L Coe
Aug 12, 2014·Urology·James C Williams
Jan 24, 2015·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Andrew P EvanFredric L Coe
Aug 7, 2014·Urolithiasis·Pietro Manuel FerraroGambaro Giovanni
Aug 7, 2014·Urolithiasis·James C WilliamsAndrew P Evan
Aug 12, 2014·Urolithiasis·Andrew P EvanJames E Lingeman
Aug 15, 2014·Urolithiasis·Saeed R Khan, Benjamin K Canales
Jul 28, 2016·Nature Reviews. Nephrology·Fredric L CoeAndrew P Evan
Aug 24, 2016·Nature Reviews. Urology·Michael S BorofskyJames E Lingeman
Oct 27, 2016·Journal of Nephrology·Giovanni GambaroUNKNOWN Consensus Conference Group
Dec 14, 2017·Urolithiasis·Léa HuguetEmmanuel Letavernier
Apr 20, 2014·Urologia·Andrea Tasca, Ciro Ammendola
Aug 22, 2017·The Journal of Urology·James C WilliamsJames E Lingeman
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Feb 24, 2019·Nature Reviews. Nephrology·Felix KnaufRichard A Flavell
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Aug 2, 2018·American Journal of Physiology. Renal Physiology·Andrew P EvanElaine M Worcester
Dec 28, 2019·Journal of Endourology·Andrew P EvanJames E Lingeman
May 10, 2017·Investigative and Clinical Urology·Mohammed AlenziBilal Ahmad Tantry
Nov 26, 2019·Journal of Endourology·Michael S BorofskyJames E Lingeman
Dec 4, 2016·Urolithiasis·James C WilliamsJames E Lingeman
May 31, 2013·American Journal of Physiology. Renal Physiology·Kristin J BergslandFredric L Coe
May 26, 2021·Nature Reviews. Urology·Mayandi SivaguruBruce W Fouke

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