Plaque Morphology as Predictor of Late Plaque Events in Patients With Asymptomatic Type 2 Diabetes: A Long-Term Observational Study

JACC. Cardiovascular Imaging
David A HalonBasil S Lewis

Abstract

The authors used coronary computed tomography angiography (CTA) to determine plaque characteristics predicting individual late plaque events precipitating acute coronary syndromes (ACS) in a cohort of asymptomatic type 2 diabetic patients. In patients with coronary artery disease, CTA plaque characteristics may predict mid-term patient events. Asymptomatic patients with diabetes 55 to 74 years of age with no history of coronary artery disease (N = 630) underwent baseline 64-slice CTA and detailed plaque level analysis. All subsequent clinical events were recorded and adjudicated. In patients who developed ACS, culprit plaque was identified at invasive angiography and its precursor located on the baseline CTA. Plaque characteristics predicting an ACS-associated culprit plaque event were analyzed by time to event accounting for inpatient clustering of plaques and competing events. Among 2,242 plaques in 499 subjects, 24 ACS culprit plaques were identified in 24 subjects during median follow-up of 9.2 years (interquartile range: 8.4 to 9.8 years). Plaque volume (upper vs. lower quartile hazard ratio [HR]: 6.9; 95% confidence interval [CI]: 1.6 to 30.8; p = 0.011), percentage of low-density plaque content <50 Hounsfield units (HR: ...Continue Reading

Citations

Jan 30, 2020·Diagnostics·Michael Y HeneinFederico Vancheri
Aug 15, 2020·European Heart Journal Cardiovascular Imaging·Simon DeseiveJörg Hausleiter
Mar 18, 2020·European Cardiology·Thomas D HeseltineMichael Fisher
Sep 25, 2019·Diagnostics·Federico VancheriMichael Y Henein
May 27, 2020·Heart·Mohammed N MeahDavid E Newby
Aug 9, 2020·JACC. Cardiovascular Imaging·Todd C Villines, Austin A Robinson
Dec 19, 2020·Journal of the American College of Cardiology·Leslee J Shaw, Y Chandrashekhar
May 8, 2021·Journal of the American College of Radiology : JACR·UNKNOWN Expert Panel on Cardiac ImagingSuhny Abbara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.