Plaque vulnerability in internal carotid arteries with positive remodeling.

Cerebrovascular Diseases Extra
Toshiyasu MiuraKosei Ojika

Abstract

This study aimed to evaluate the efficacy of assessing positive remodeling for predicting future stroke events in the internal carotid artery. We therefore assessed narrowing of the carotid artery lumen using multidetector-row computer tomography (MDCT) angiography and carotid plaque characteristics using black-blood (BB) magnetic resonance (MR). We retrospectively selected 17 symptomatic and 11 asymptomatic lesions with luminal narrowing >50%. We compared remodeling parameters of luminal stenosis (remodeling ratio, RR/remodeling index, RI) using MDCT and MR intensities of atherosclerotic plaque contents using the BB technique (relative signal intensity, rSI). We also confirmed the validity of the relationship between MR intensity and atherosclerotic plaque contents by histology. The levels of biological markers related to vessel atherosclerosis were measured. Plaque lesions with positive remodeling in carotid arteries were associated with a significantly higher prevalence of stroke compared with plaques with negative remodeling (p < 0.05). Radiologic and histologic analyses determined that plaques with positive remodeling had higher signal intensities (with respect to their lipid-rich content or to hemorrhage) compared with ne...Continue Reading

Citations

Apr 3, 2012·Medical Engineering & Physics·Tristan BelzacqAlexandre Delache
Mar 5, 2016·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Tobias SaamAndreas Helck
Mar 4, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Kenji FukudaHatsue Ishibashi-Ueda
Dec 3, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hiroyuki KatanoSatoru Takahashi
Nov 5, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Chao FengJing Huang
Mar 26, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hiroyuki KatanoKazuo Yamada
Jul 5, 2012·Computer Methods in Biomechanics and Biomedical Engineering·Tristan BelzacqAlexandre Delache
Jan 13, 2018·AJNR. American Journal of Neuroradiology·L SabaUNKNOWN Vessel Wall Imaging Study Group of the American Society of Neuroradiology
Apr 18, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zhehao HuZhaoyang Fan
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Milad GhasemiCaitríona Lally
Nov 7, 2020·The International Journal of Neuroscience·Jun ZhouXue-Ping Liu
Jun 12, 2021·Frontiers in Aging Neuroscience·Yingzhe WangMei Cui

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