Plasma- and urine concentrations of nitrite/nitrate and cyclic Guanosinemonophosphate in intrauterine growth restricted and preeclamptic pregnancies

Archives of Gynecology and Obstetrics
Barbara SchiesslKlaus Friese

Abstract

The Nitric Oxide (NO) system plays an important role in the establishment and maintenance of the feto-placental circulation. Research on the pathogenesis of preeclampsia in several studies has established the involvement of the NO-system in preeclampsia and fetal intrauterine growth restriction (IUGR). In the presented study we analyzed the urine and plasma concentrations of nitrite/nitrate, the stable endproducts of NO and its second messenger, cyclic Guanosinemonophosphate (cGMP) in normal, preeclamptic and IUGR pregnancies. In total 76 patients were investigated in a prospective study for repeated determination of plasma and urinary levels of nitrate/nitrite and cGMP: 49 patients with a normal course of pregnancy, 14 patients with fetal IUGR and 13 patients with preeclampsia were included into the study. Plasma and urine Nitrite/Nitrate-concentrations were determined using a Colorimetric Assay (Cayman Inc., USA), concentrations of the second messenger cGMP in plasma and urinary samples were determined with a J(125)-Radio-Immuno-Assay (ibl Inc., Germany). The Stat View Program (Abacus Concepts, Inc., Berkeley, CA, 1992-1998) was used for statistical analysis, a P value <0.05 was considered significant. Analyzing the data with...Continue Reading

References

Jul 1, 1991·British Journal of Obstetrics and Gynaecology·R PijnenborgA van Assche
Oct 1, 1994·American Journal of Obstetrics and Gynecology·S P SeligmanS B Abramson
Aug 1, 1994·British Journal of Obstetrics and Gynaecology·J W MeekinsA van Asshe
Mar 1, 1996·American Journal of Obstetrics and Gynecology·S T DavidgeJ M Roberts
Dec 1, 1996·The Journal of Obstetrics and Gynaecology Research·S BegumM Mochizuki
Mar 3, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R Di IorioE V Cosmi
Sep 7, 1999·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·E BeinderC Baylis
Nov 20, 2002·American Journal of Obstetrics and Gynecology·Jan J BrosensIvo A Brosens
Jul 10, 2003·Acta Obstetricia Et Gynecologica Scandinavica·Thajasvarie NaickerRobert Pijnenborg
Jun 29, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Barbara SchiesslUdo Jeschke

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Citations

Apr 2, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Hatice YükselHayriye Ak Yıldırım
Oct 31, 2012·Current Opinion in Obstetrics & Gynecology·Madhavi KalidindiJoseph Aquilina
Aug 4, 2009·Reproductive Biology and Endocrinology : RB&E·Gloria ValdesJanae Joyner-Grantham
Jun 11, 2015·International Journal of Molecular Sciences·Elizabeth C Cottrell, Colin P Sibley
Jun 20, 2015·Indian Journal of Clinical Biochemistry : IJCB·Shalini SinghJayashree Bhattacharjee
Oct 13, 2016·The Journal of Endocrinology·D S Boeldt, I M Bird
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Patricio López-JaramilloMarcos López
Nov 3, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Frank T SpradleyJoey P Granger
Oct 20, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Wentao YuRaouf A Khalil
Mar 2, 2019·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Hui ChenJiyun Tang
Nov 2, 2019·Cells·Xiang-Qun Hu, Lubo Zhang
Apr 7, 2020·American Journal of Physiology. Renal Physiology·Hannah R Turbeville, Jennifer M Sasser
Dec 1, 2010·Scandinavian Journal of Gastroenterology·Maria H LönnkvistPer M Hellström
Aug 9, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Hongmei Qu, Raouf A Khalil
Jun 15, 2019·International Journal of Molecular Sciences·Weronika Dymara-Konopka, Marzena Laskowska
Nov 12, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Laura E CoatsBarbara T Alexander

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