Abstract
Decreased circulating 25-hydroxyvitamin D (25[OH]D) and increased inflammatory marker concentrations have been reported separately in canine cancer. Correlations between the two exist in humans, but little work has examined links in dogs. This study aimed to determine plasma 25(OH)D and inflammatory marker concentrations in healthy dogs and dogs with cancer and to assess correlations in each group. Newly diagnosed dogs with B-cell lymphoma (B-cell, n = 25), T-cell lymphoma (T-cell, n = 9), osteosarcoma (OSA, n = 21), and mast cell tumour (MCT, n = 26) presenting to a tertiary oncology centre, and healthy dogs (n = 25), were enrolled. Plasma samples were analysed for 25(OH)D, C-reactive protein (CRP), haptoglobin (HP), serum amyloid A (SAA), alpha-1-acid glycoprotein (AAG), and 13 chemokines and cytokines. Dogs with B-cell had decreased plasma 25(OH)D (P = .03), and increased plasma CRP, AAG, HP, KC-like and MCP-1 concentrations (P < =.001, .011, <.001, .013 and .009, respectively) compared with healthy dogs. Plasma CRP, HP and SAA concentrations were increased in dogs with OSA compared with healthy dogs (P = .001, .010 and .027, respectively). No differences were noted in dogs with T-cell and MCT. Negative correlations were obs...Continue Reading
References
Apr 1, 1984·Hematological Oncology·F R AppelbaumJ C Wulff
Feb 22, 2002·Journal of the American Society of Nephrology : JASN·Daniel ZehnderMartin Hewison
Dec 22, 2004·Veterinary Research Communications·B GerberC E Reusch
May 20, 2005·Veterinary Clinical Pathology·Jose Joaquýn CeronSilvia Martýnez-Subiela
Aug 12, 2006·The Veterinary Journal·R MischkeP D Eckersall
Oct 21, 2010·Veterinary Research Communications·Masashi YukiHiroshi Itoh
Oct 30, 2010·The Journal of Small Animal Practice·V J AdamsJ L N Wood
Dec 2, 2010·The Journal of Clinical Endocrinology and Metabolism·A Catharine RossSue A Shapses
Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kristina EdfeldtRobert L Modlin
Feb 10, 2011·Veterinary and Comparative Oncology·J A PerryS W Dow
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jul 20, 2011·The Veterinary Journal·A GallerM Willmann
Jul 30, 2011·The Journal of Small Animal Practice·A G GowR J Mellanby
Oct 1, 2011·The Journal of Clinical Endocrinology and Metabolism·Amy L SkverskyMichal L Melamed
Oct 26, 2011·The British Journal of Nutrition·Joseph J WakshlagLili Tian
Dec 14, 2011·The American Journal of Clinical Nutrition·Andrew DuncanDenis St J O'Reilly
Jun 5, 2012·The Veterinary Record·D ChaseK Pratschke
Sep 19, 2012·The Journal of Veterinary Medical Science·Katsumi IshiokaToshinori Sako
Feb 28, 2013·Veterinary Pathology·V E ValliF Scott
Jul 19, 2013·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Stefania CasellaGiuseppe Piccione
Aug 21, 2013·Journal of Veterinary Internal Medicine·C T RosaE Dvir
Sep 3, 2013·The Veterinary Journal·Lise Nikolic NielsenAnnemarie T Kristensen
Oct 15, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Doris M HummelEnikő Kállay
Mar 29, 2014·PloS One·Rawia A GhashutDonald C McMillan
Jul 22, 2014·Veterinary and Comparative Oncology·K A SeltingR Backus
Aug 8, 2014·Experimental Animals·Francesco FazioGiuseppe Piccione
Jan 30, 2015·Nutrition Research·Mariana Costa Silva, Tania Weber Furlanetto
Mar 31, 2015·Journal of Veterinary Internal Medicine·J W SpooJ J Wakshlag
Jul 7, 2015·PloS One·Marte C LiefaardAbbas Dehghan
Aug 27, 2015·Journal of Veterinary Internal Medicine·H TitmarshR J Mellanby
Feb 26, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P SrikanthUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Research Group
Aug 23, 2016·Journal of Nutritional Science·Lauren R Young, Robert C Backus
Nov 5, 2016·The Veterinary Journal·Jennifer L WillcoxMarlene L Hauck
Nov 20, 2016·Veterinary Immunology and Immunopathology·Jerome CalvalidoJ Paul Woods
Jul 1, 2017·The Journal of Veterinary Medical Science·Dong-In KimMhan-Pyo Yang
Sep 25, 2017·Journal of Veterinary Internal Medicine·N WeidnerA Verbrugghe
Nov 21, 2017·Journal of Nutritional Science·Lauren R Young, Robert C Backus
Mar 29, 2018·PloS One·Jared A JaffeyAmy E DeClue
Jun 7, 2018·The Veterinary Journal·J A JaffeyA E DeClue
Sep 27, 2018·American Journal of Veterinary Research·Jared A JaffeyAmy E DeClue
Sep 27, 2018·American Journal of Veterinary Research·Jared A JaffeyAmy E DeClue