Plasma 5-hydroxytryptamine (5-HT) in migraine during an attack-free period

Headache
Eiichiro NagataNorihiro Suzuki

Abstract

We measured the plasma 5-HT, 5-hydroxytryptophan (5-HTP), and tryptophan levels in controls, migraine patients with aura (MWA), and migraine patients without aura (MWoA) during an attack-free period. Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the pathophysiology of migraine. The precise relationship between 5-HT and migraine, however, remains unclear. Blood samples in controls, MWA, and MWoA patients during an attack-free period were collected from brachial arteries and analyzed using HPLC. The plasma tryptophan and 5-HTP levels were not significantly different between the controls and migraine patients (either MWA or MWoA). However, the plasma 5-HT level in the MWA patients was significantly lower than that in the controls and MWoA patients. The present data suggest that reduced levels of 5-HT in MWA may result from either a dysfunction in the enzymes involved in serotonin biosynthesis or a dysfunction in 5-HT release or uptake from platelets and lymphocytes. These findings indicate the existence of a serotonin metabolism dysfunction in MWA patients that may differ from the state of serotonin metabolism in MWoA patients.

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Citations

Feb 4, 2010·Pediatrics in Review·Kathi J Kemper, Cora Collette Breuner
May 12, 2009·Neuroscience Research·Eiichiro NagataShigeharu Takagi
Nov 28, 2006·Neuroscience Research·Eiichiro NagataNorihiro Suzuki
Nov 22, 2008·European Journal of Clinical Investigation·N M Kushnir-SukhovD D Metcalfe
Jul 8, 2008·Epilepsy Research·Salvatore GrossoPaolo Balestri
Apr 29, 2014·Thrombosis Research·Elisa DaneseGiuseppe Lippi
Jun 29, 2014·Cephalalgia : an International Journal of Headache·Vincenzo GuidettiOliviero Bruni
Dec 19, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Simona D FrederiksenLars Edvinsson
Dec 24, 2011·Molecular and Cellular Biochemistry·Masakazu IshiiYuji Kiuchi
Dec 1, 2012·Rinshō shinkeigaku = Clinical neurology·Eiichiro Nagata
Feb 7, 2020·Neurological Research·Nermin TanikLevent Ertugrul Inan
Jun 19, 2019·International Journal of Molecular Sciences·Giuseppe TardioloEmanuela Mazzon
Feb 15, 2017·The Journal of Headache and Pain·Claudia Francesca GaspariniLyn Robyn Griffiths
Mar 16, 2018·Frontiers in Neurology·Antonietta MessinaMarco Carotenuto

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