Plasma 5-hydroxytryptamine constricts equine digital blood vessels in vitro: implications for pathogenesis of acute laminitis

Equine Veterinary Journal
S R Bailey, J Elliott

Abstract

Cumulative concentration response curves to 5-hydroxytryptamine (5-HT; 10(-10)-10(-4) mol/l) were constructed using isolated rings of equine digital, facial, tail and coronary arteries (endothelium intact). 5-HT was 17.7 and 41 times more potent as a vasoconstrictor of digital arteries than facial and tail arteries respectively. Removal of the endothelium increased the vasoconstrictor potency of 5-HT in the facial artery by 3.7-fold (P<0.05) but did not alter the sensitivity of digital arteries to 5-HT. Coronary arteries failed to contract to 5-HT. Coronary arteries pre-contracted with U44069 showed concentration dependent relaxation to 5-HT, a response which was partially dependent on the presence of the endothelium. No vasorelaxant effects were found in the digital or facial arteries. The concentration of 5-HT in platelet poor and platelet rich equine plasma was found to be 6.70+/-1.1 x 10(-8) mol/l and 1.77+/-0.36 x 10(-6) mol/l (mean +/-s.e.) respectively by high performance liquid chromatography (HPLC). Plasma which contained no detectable platelets had a 5-HT concentration of 1.12+/-0.48 x 10(-8) mol/l. Isolated digital arteries constricted when exposed to dilutions of platelet poor and platelet depleted equine plasma. Th...Continue Reading

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Citations

Feb 21, 2004·The Veterinary Journal·Simon R BaileyJonathan Elliott
Apr 16, 1998·Equine Veterinary Journal·N E Robinson
Apr 5, 2003·Applied and Environmental Microbiology·S R BaileyJ Elliott
Jul 7, 2011·American Journal of Veterinary Research·Lisa M KatzJonathan Elliott
Jul 12, 2014·European Journal of Pharmacology·Rock Allister LapoMohamed Yassine Mallem
Apr 26, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Nicola J Menzies-GowJ Elliott
Nov 24, 1999·The Veterinary Quarterly·M M Sloet van Oldruitenborgh-Oosterbaan
Apr 13, 2010·The Veterinary Clinics of North America. Equine Practice·Julie B Engiles
Apr 13, 2010·The Veterinary Clinics of North America. Equine Practice·Gabriel J MilinovichDarren J Trott
Nov 17, 2006·Research in Veterinary Science·A HammondF M Cunningham
Jan 19, 2007·Equine Veterinary Journal·S R Bailey, J Elliott
May 20, 2008·Equine Veterinary Journal·J A KeenJ E Nally
Sep 9, 2006·Journal of Veterinary Pharmacology and Therapeutics·Y BerhaneS R Bailey
Apr 11, 2000·Research in Veterinary Science·S R BaileyF Cunningham
Sep 30, 2016·PloS One·Ruth A MorganPatrick W F Hadoke
Sep 19, 2003·American Journal of Veterinary Research·Jonathan ElliottSimon R Bailey
Sep 8, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Sara C TorfsSiska M Croubels
Jul 14, 2017·Journal of Veterinary Pharmacology and Therapeutics·C ZizzadoroC Belloli
Nov 5, 2005·Journal of Applied Physiology·John F PeroniTom P Robertson
Feb 5, 2008·American Journal of Veterinary Research·Nicola J Menzies-GowJonathan Elliott
May 19, 2004·Equine Veterinary Journal·R F NevilleF V Keyte
Nov 28, 2000·Equine Veterinary Journal·S R BaileyJ Elliott
Jun 15, 2006·The Journal of Nutrition·Jonathan Elliott, Simon R Bailey

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