PMID: 43581Nov 1, 1979

Plasma acetate concentrations during canine haemorrhagic shock

Scandinavian Journal of Clinical and Laboratory Investigation
M KveimJ E Bredesen

Abstract

Acetate, pyruvate, lactate and NEFA concentrations, as well as acid-base-parameters were followed during bleeding, stable hypotension and re-infusion in five dogs. Mean arterial blood pressures were kept at 30 mmHg during the shock phase. An increase in acetate concentrations (P less than 0.01) was found in arterial as well as in venous plasma samples. The maximal mean acetate concentration was 0.19 mmol/l (during reinfusion) as compared to 0.06 mmol/l prior to bleeding. There was no difference between arterial and inferior caval venous concentrations. A definite correlation (r = 0.81, P less than 0.02) was found between blood pyruvate and plasma acetate concentrations. There was no correlation between plasma glucose or NEFA and acetate concentrations or between blood excess lactate and plasma acetate. The plasma acetate accumulation was negligible compared to the concomitant lactate accumulation (1:60), and did not contribute to the metabolic acidosis of shock. The correlation between acetate and pyruvate concentrations may indicate that pyruvate is the main substrate of acetate production in hypovolemic shock.

References

Feb 15, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Kveim, J E Bredesen
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Citations

Feb 1, 1982·Pflügers Archiv : European journal of physiology·R P SteffenF J Haddy
Feb 29, 2008·Critical Care : the Official Journal of the Critical Care Forum·Bala Venkatesh, Thomas J Morgan
Oct 16, 2013·The Journal of Surgical Research·Ricarda RohrigHerbert de Groot
Apr 27, 2018·Military Medical Research·Ying WangHong Zhou
Nov 1, 1979·Scandinavian Journal of Clinical and Laboratory Investigation·M Kveim, R Nesbakken
Nov 1, 1979·Scandinavian Journal of Clinical and Laboratory Investigation·M KveimJ E Bredesen

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