Plasma ADAMTS-13 protein is not associated with portal hypertension or hemodynamic changes in patients with cirrhosis

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Signe WieseSøren Møller

Abstract

Activated hepatic stellate cells synthesize the matrix metalloprotease ADAMTS13, which may be involved in the development of liver cirrhosis and portal hypertension. Plasma ADAMTS13 activity has been reported as both increased and decreased in cirrhosis, but ADAMTS13 protein has not previously been examined. To evaluate ADAMTS13 protein in the hepatic circulation and the relation to disease severity, portal pressure, and systemic hemodynamics in cirrhotic patients. Sixty-one cirrhotic patients (Child class: A=22; B=21; C=18) and nine healthy controls underwent a liver vein catheterization with measurement of splanchnic and systemic hemodynamics, and plasma ADAMTS13 protein concentration in a hepatic vein and the femoral artery. ADAMTS13 protein concentrations were increased in cirrhotic patients compared with controls (774ng/ml [IQR: 585-955] vs. 538ng/ml [IQR: 484-631], p<0.03). There were no significant correlations to MELD score, Child Pugh score, portal pressure, nor systemic vascular resistance or cardiac output. The increased concentration of ADAMTS13 protein in the hepatic circulation may reflect an increased number of active hepatic stellate cells in cirrhosis. However, ADAMTS13 was unrelated to portal hypertension and ...Continue Reading

References

Nov 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H YoshijiH Fukui
Feb 28, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Søren MøllerFlemming Bendtsen
Apr 2, 2005·British Journal of Haematology·Koichi KokameToshiyuki Miyata
May 13, 2006·Journal of Thrombosis and Haemostasis : JTH·M NiiyaX L Zheng
Nov 15, 2012·Biochimica Et Biophysica Acta·John P IredaleNeil C Henderson
Jul 23, 2014·Scandinavian Journal of Gastroenterology·Troels M BuskSøren Møller
Aug 13, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Philipp A ReukenTony Bruns

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Citations

May 26, 2016·Internal and Emergency Medicine·Stefano LancellottiRaimondo De Cristofaro
Feb 16, 2019·European Journal of Gastroenterology & Hepatology·Lasse L LangholmSøren Møller
Jun 1, 2018·Gastroenterology Research and Practice·Tomasz MikułaAlicja Wiercińska-Drapało

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