Plasma ADAMTS13 activity may predict early adverse events in living donor liver transplantation: observations in 3 cases

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Saiho KoYoshiyuki Nakajima

Abstract

A disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS13) is a metalloproteinase that specifically cleaves the multimeric von Willebrand factor (VWF). Deficiency of ADAMTS13 increases the unusually large VWF multimers (UL-VWFM), which leads to platelet clumping and/or thrombus formation, resulting in microcirculatory disturbance. We serially determined the activity of plasma ADAMTS13, together with VWF antigen (VWF:Ag) and UL-VWFM, in association with the development of early graft dysfunction in 3 liver transplant recipients and 4 patients with major hepatectomy as controls. In case 1, ADAMTS13 activity decreased markedly from 108% to less than 3% with concomitant thrombocytopenia on posttransplantation day 7, when acute rejection occurred. Simultaneously, UL-VWFM were detected. During the second episode of rejection, VWF:Ag increased to 368% with the appearance of UL-VWFM, while ADAMTS13 activity was as low as 18%, indicating an imbalance between a large amount of UL-VWFM and low activity of ADAMTS13. Administration of fresh frozen plasma (FFP) together with treatment for acute rejection resulted in an improvement of ADAMTS13 activity and disappearance of the UL-VWFM. In case 2, ADAMTS13 activit...Continue Reading

References

Jan 1, 1993·Alcohol and Alcoholism. Supplement·S UrashimaA Takada
Nov 26, 1998·The New England Journal of Medicine·H M Tsai, E C Lian
Mar 30, 1999·Transplantation·M A ChatzipetrouA G Tzakis
Jul 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J K MaringM J Slooff
Jun 27, 2002·Transplantation·G Aravinda Upadhya, Steven M Strasberg
Aug 23, 2002·The New England Journal of Medicine·Joel L Moake
Apr 5, 2003·Intensive Care Medicine·Chaker Ben HamidaFrançois Stéphan
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·Z M Ruggeri
Sep 17, 2003·Transplant Infectious Disease : an Official Journal of the Transplantation Society·K RamasubbuR K Avery
Nov 20, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Yuichi NakazawaShinichi Miyagawa
Feb 26, 2004·The Journal of Biological Chemistry·John E PimandaPhilip J Hogg
Mar 19, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alfredo MarzanoMario Rizzetto
Apr 28, 2005·Blood·Masahito UemuraYoshihiro Fujimura
Jul 26, 2005·Transplantation·Sumihito TamuraMasatoshi Makuuchi

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Citations

Jan 8, 2010·International Journal of Hematology·Masahito UemuraHiroshi Fukui
Sep 21, 2013·Thrombosis Research·Savita RangarajanLouis Aledort
Oct 1, 2014·Blood Reviews·Annelies VerbiestDaan Dierickx
May 9, 2009·Thrombosis Research·Toshihiko KobayashiShuji Isaji
May 9, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I T A PereboomT Lisman
Jun 27, 2006·Journal of Thrombosis and Haemostasis : JTH·T Matsushita, H Saito
Mar 9, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Shugo MizunoShuji Isaji
Mar 3, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Delphine ArniValérie A McLin
Apr 8, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G C G HugenholtzT Lisman
Dec 24, 2005·Expert Opinion on Biological Therapy·Shinichi MatsumotoCamillo Ricordi
Jul 15, 2015·World Journal of Hepatology·Saiho KoYoshiyuki Nakajima
Nov 16, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Siu Ling WongDenisa D Wagner
Dec 17, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Maureen J M WernerRobert J Porte

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