PMID: 22558798May 9, 2012Paper

Plasma adenosine deaminase isoform 2 in cancer patients undergoing chemotherapy

British Journal of Biomedical Science
E L Roberts, O T Roberts

Abstract

Adenosine deaminase (AD), a purine salvage enzyme, exists as AD isoform 1 (AD1) and AD isoform 2 (AD2). Plasma AD has been advocated for the screening and monitoring of cancer, as AD2 activity is increased in conditions associated with tumour growth. Plasma AD2 was measured before and seven to 10 days after the first dose of chemotherapy in patients with different tumours. A 'tumour regression score' was assessed independently based on radiological changes seen in the tumour following completion of chemotherapy. Changes in plasma AD2 were then compared with the tumour regression score. Following first-dose chemotherapy, plasma AD2 decreased on average from 22.7 +/- 10.5 U/L to 15.0 +/- 4.6 U/L. The percentage decrease in plasma AD2 correlated with the tumour regression score (r=0.5, P=0.028). These data suggest plasma AD2 may have a role in determining tumour response to treatment.

Citations

Dec 20, 2018·Immunological Reviews·Leen MoensIsabelle Meyts
Jun 17, 2014·Medicinal Research Reviews·Antoni CortésVicent Casadó
Sep 25, 2016·Cellular and Molecular Life Sciences : CMLS·Yuliia KaljasAndrey V Zavialov
Jul 15, 2016·Redox Report : Communications in Free Radical Research·Necip PirinççiKadir Ceylan

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