Plasma adiponectin is associated with plasma brain natriuretic peptide and cardiac function in healthy subjects

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Takahiro OharaMasafumi Kitakaze

Abstract

The aim of this study was to evaluate the relationship between the plasma adiponectin level, plasma brain natriuretic peptide (BNP) level, and cardiac function in healthy subjects. We obtained clinical data and performed blood tests, including measurement of the plasma adiponectin and BNP levels, in 1,538 healthy persons from Arita-cho, a rural area of Japan. Six hundred and eight subjects also underwent echocardiography. There was a significant positive correlation between their plasma BNP and adiponectin levels in simple regression analysis (standardized regression coefficient [beta] = 0.34). Multivariate regression analysis revealed that the plasma adiponectin level was independently associated with the plasma BNP level (beta = 0.12), as well as with the age (beta = 0.22), male gender (beta = -0.26), waist circumference (beta = -0.16), and the plasma levels of high-density lipoprotein cholesterol (beta = 0.13), triglycerides (beta = -0.16), aspartate aminotransferase (beta = 0.08), gamma-glutamyl transpeptidase (beta = -0.10), uric acid (beta = -0.07), and creatinine (beta = 0.08). We also found a link between plasma adiponectin and the left atrial diameter index (beta = 0.08) or left ventricular diameter index (beta = 0.11)...Continue Reading

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Citations

Jan 15, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Tohru Funahashi, Yuji Matsuzawa
May 15, 2010·International Journal of Pediatrics·L B MänhardtR Buchhorn
Feb 7, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Mohamed F AlgahimHeinrich Taegtmeyer
Apr 16, 2009·International Heart Journal·Shinya TosaHiroshi Ito
May 30, 2009·Journal of the American College of Cardiology·Osamu TsukamotoMasafumi Kitakaze
May 30, 2009·Journal of the American College of Cardiology·Lisa C Costello-Boerrigter, John C Burnett
Aug 10, 2011·Journal of cardiology·Takahiro OharaMasafumi Kitakaze
Jun 29, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kaori NakanishiKeiko Yamauchi-Takihara
May 28, 2010·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Sasiwarang Goya WannametheeNaveed Sattar
Apr 6, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Chun-Yen ChenMasafumi Kitakaze
Jun 17, 2020·Cardiovascular Endocrinology & Metabolism·Steven R HorbalAurelian Bidulescu
Jun 13, 2021·Cardiovascular Research·Albert Youngwoo JangKwang Kon Koh

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