Plasma adrenomedullin and carotid atherosclerosis in atherothrombotic ischemic stroke

Journal of Hypertension
N HosomiJames A Koziol

Abstract

Adrenomedullin is known to exert anti-atherosclerotic actions by inhibiting proliferation and migration of smooth muscle cells in vitro. Here we examine the relationship between the plasma concentration of adrenomedullin and ultrasonographic characteristics of carotid arteries both in ischemic stroke and in the absence of cerebrovascular disease. We studied 61 patients with atherothrombotic ischemic stroke in the chronic phase and 50 patients without any cerebrovascular disease. Intima-media thickness and vascular lumen diameters were evaluated by carotid ultrasonography. Plasma mature-adrenomedullin was determined by radioimmunoassay. Plasma mature-adrenomedullin in the patients with atherothrombotic ischemic stroke in the chronic phase (2.01 +/- 0.58 fmol/ml) was significantly higher than that in the patients without any cerebrovascular disease (1.24 +/- 0.18 fmol/ml, P < 0.001). With multiple regression analysis, plasma mature-adrenomedullin was found to be predicted by: stroke status (atherothrombotic ischemic stroke versus no cerebrovascular disease), diabetes status (yes/no), left ventricular ejection fraction, internal carotid artery intima-media thickness, and common carotid artery pressure strain elastic modulus (R = 0...Continue Reading

References

Nov 1, 1994·Journal of Internal Medicine·D E Grobbee, M L Bots
Feb 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J PerssonG Berglund
Apr 30, 1993·Biochemical and Biophysical Research Communications·K KitamuraT Eto
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·X WangG Z Feuerstein
Feb 1, 1996·Journal of Hypertension·H KanoJ Yoshikawa
Mar 26, 1998·Biochemical and Biophysical Research Communications·K KitamuraT Eto
Jun 27, 1998·The Journal of Biological Chemistry·A KuboH Matsuo

❮ Previous
Next ❯

Citations

Dec 5, 2012·Cerebrovascular Diseases·Naohisa HosomiMasayasu Matsumoto
Oct 16, 2015·Journal of Atherosclerosis and Thrombosis·Tomohisa NezuMasayasu Matsumoto
Nov 4, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Tomohiro KawanoKazuyuki Nagatsuka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.