Plasma adrenomedullin level and development of hypertension

Journal of Human Hypertension
J KatoT Eto

Abstract

The hypotensive peptide adrenomedullin (AM) is assumed to act as a factor inhibitory on elevation of blood pressure and on progression of the hypertensive organ damage, and plasma AM levels are elevated in patients with hypertension. The aim of the present study is to explore whether or not a rise in plasma AM levels precedes the development of hypertension. Normotensive local residents without apparent cardiovascular or renal disease (n = 177) were divided into low and high AM groups based on the median concentration of AM in plasma (11.9 fmol/ml), and followed up for 3 years for development of hypertension. The incidence of hypertension was higher in the residents with high AM than low AM levels (27.8 vs 11.5%, P < 0.01), whereas a similar analysis of plasma levels of atrial or brain natriuretic peptides revealed no such difference. The plasma AM level was found to be a significant parameter for the development of hypertension in a univariate analysis (P < 0.01), but not in a multivariate analysis. Meanwhile, the plasma AM level was significantly (P < 0.01) correlated with age and body mass index (BMI), two variables independently significant for the development of hypertension. The present findings suggest that an elevation ...Continue Reading

References

Apr 30, 1993·Biochemical and Biophysical Research Communications·K KitamuraT Eto
Jun 1, 1996·Journal of the American College of Cardiology·N ArakawaK Hiramori
Oct 6, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·H OhtaK Kangawa
Jan 5, 2002·Circulation·Tatsuo ShimosawaToshiro Fujita
Dec 18, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Johji KatoTanenao Eto
Mar 13, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Johji KatoTanenao Eto
Feb 13, 2004·The New England Journal of Medicine·Thomas J WangRamachandran S Vasan
May 4, 2004·Journal of the American College of Cardiology·Mandeep R MehraEdward D Frohlich
Mar 25, 2005·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·C LetiziaU Di Mario
Sep 6, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Johji KatoTanenao Eto
Sep 13, 2005·Regulatory Peptides·Takuo NambuKazuwa Nakao

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Citations

Aug 19, 2008·Cardiovascular Research·Donghao JinNoritoshi Nagaya
Jul 30, 2011·European Journal of Endocrinology·Bernard M Y CheungUNKNOWN Investigators of Hong Kong Cardiovascular Risk Factor Prevalence Study
Nov 16, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kwok Leung OngKaren S L Lam
Aug 24, 2010·Regulatory Peptides·Donghao JinKenji Kangawa
Feb 6, 2021·Journal of Clinical Medicine·Katarzyna CzajkowskaTomasz Hryszko

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