Plasma alcohol concentrations in patients following paclitaxel infusion

Cancer Chemotherapy and Pharmacology
L K WebsterM J Millward

Abstract

Paclitaxel is formulated in 50% Cremophor El and 50% ethanol such that patients receiving paclitaxel also receive a significant amount of each of these solvents. The aim of this study was to measure the plasma alcohol levels in patients treated with paclitaxel. A total of 12 patients who were enrolled in phase II trials of non-small-cell lung cancer, breast cancer or ovarian cancer received 175 mg/m2 paclitaxel given as a 3-h infusion. Blood samples were obtained prior to and immediately following the infusion, and plasma ethanol concentrations were measured enzymatically. The dose of ethanol delivered with the paclitaxel ranged from 20.0 to 28.9 ml. No alcohol was detected in pre-dose plasma, but 8 of 12 patients had detectable levels in post-infusion plasma, with 0.033 g/dl being the highest concentration. The elimination rate of alcohol approximates the infusion rate when paclitaxel is given over 3h, resulting in low or undetectable levels in most patients. However, in patients receiving an equivalent dose of paclitaxel given as a 1-h infusion, the plasma alcohol levels will likely be high enough for significant pharmacological effects to occur.

References

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Citations

Sep 28, 1998·Cancer Chemotherapy and Pharmacology·M J Egorin
Mar 15, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·L Slovacek, B Slovackova
May 28, 2011·Medical Oncology·Sadık MuallaoğluNilüfer Güler
Oct 10, 1997·Pharmacotherapy·C M Kearns
Sep 26, 2017·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Serena ChengLuigi Brunetti
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Oct 24, 2018·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Toshinari YagiFumio Imamura
Apr 18, 2019·Oncology Research and Treatment·Hansjakob FriesFlorian Lordick

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