Plasma aldosterone response to ACTH in subtypes of primary aldosteronism

Clinical and Experimental Pharmacology & Physiology
M StowasserR D Gordon

Abstract

1. Aldosterone responsiveness to ACTH was compared in eleven patients with angiotensin-unresponsive (AII-U) aldosterone-producing adenomas (APA), 16 with AII-responsive (AII-R) APA and 19 with bilateral adrenal hyperplasia (BAH). 2. After overnight recumbency, aldosterone levels were highest in AII-U APA and lowest in BAH. Following 2 h of upright posture, however, levels were similar among the three groups. 3. During ACTH infusion, aldosterone levels in AII-U and AII-R APA were similar, and higher than those in BAH. Because of the higher basal level, the percentage rise in aldosterone was lower in AII-U APA compared with the other groups, as was the ratio of per cent aldosterone rise to per cent cortisol rise. 4. Slightly but significantly reduced plasma cortisol levels observed in the AII-R APA group may reflect secretion by AII-R APA of a cortisol-like substance that is capable of suppressing ACTH and thus adrenal cortisol production. 5. The tendency of aldosterone to follow the diurnal rhythm of ACTH in AII-U APA may thus represent an unmasking of the normal ability of ACTH to regulate aldosterone, secondary to the loss of AII responsiveness, rather than an enhancement of ACTH effect.

References

Apr 1, 1978·The Journal of Clinical Endocrinology and Metabolism·D C KemO B Holland
Jul 1, 1976·The Journal of Clinical Endocrinology and Metabolism·M SchambelanE G Biglieri
Aug 1, 1992·Journal of Hypertension·T OgawaT Eto
Nov 1, 1973·The Journal of Clinical Endocrinology and Metabolism·A GangulyA J Dowdy
Dec 1, 1993·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·S A KlemmR D Gordon

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Citations

Apr 28, 1999·Lancet·P M Stewart
Jun 1, 1996·Clinical and Experimental Pharmacology & Physiology·M StowasserR D Gordon
May 9, 2015·European Journal of Endocrinology·Masanori MurakamiYoshihiro Ogawa
Jul 26, 2016·Frontiers in Endocrinology·Nada El GhorayebAndré Lacroix
Jul 19, 2018·The Journal of Clinical Endocrinology and Metabolism·Kosuke InoueTetsuo Nishikawa
Aug 27, 2011·American Journal of Therapeutics·Hugo P Baglivo, Ramiro A Sánchez
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Tatiana ManciniGiorgio Arnaldi
Jan 10, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshihiro KitaKazuo Kitamura
Apr 3, 2021·Frontiers in Endocrinology·Jung Soo LimAdina F Turcu
Aug 21, 2021·The Journal of Clinical Endocrinology and Metabolism·Carmina Teresa FussStefanie Hahner

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