Plasma alpha2-HS glycoprotein concentrations in patients with acute myocardial infarction quantified by a modified ELISA

Clinica Chimica Acta; International Journal of Clinical Chemistry
Suresh T MathewsGeorge Grunberger

Abstract

Human alpha2-HS glycoprotein (alpha2-HSG) is synthesized and secreted by the liver into circulation. Plasma concentrations of alpha2-HSG decrease significantly following infection, inflammation and malignancy. Since increased plasma concentrations of C-reactive protein are observed in patients with acute myocardial infarction (AMI), we hypothesized that plasma concentrations of alpha2-HSG would decrease during the initial phase of AMI and begin to increase in the recovery phase. Twenty patients diagnosed with AMI were recruited for the study. A sensitive and specific ELISA was developed to assay alpha2-HSG concentrations in plasma. In AMI patients, plasma alpha2-HSG concentrations were decreased (281.3+/-25.8 mg/l, ranging from 132 to 489 mg/l on admission) compared to healthy individuals (312.3+/-9.9 mg/l, ranging from 210 to 450 mg/l) (P= 0.142). Interestingly, 40% of AMI patients demonstrated alpha2-HSG concentrations below 200 mg/l compared to none in the healthy control group. During the recovery period, alpha2-HSG concentrations begin to increase, with a mean+/-SEM of 290.1+/-22.1 mg/l. Regression analysis comparing plasma alpha2-HSG concentrations on admission to concentrations on discharge showed a significant positive ...Continue Reading

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Citations

Apr 5, 2005·Human Genetics·Catharina LavebrattPeter Arner
May 30, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Attila MolvarecJános Rigó
Jan 20, 2004·Seminars in Nephrology·Keith A HruskaKameswaran Surendran
Apr 15, 2010·Journal of Immunoassay & Immunochemistry·Amelie BäumerTi-Sun Kim
Nov 12, 2014·BioMed Research International·Ze-Lin SunYuan-Yuan Huang
Jan 18, 2017·Trends in Biotechnology·Sandeep Kumar VashistJohn H T Luong
May 1, 2009·Diabetes/metabolism Research and Reviews·Shalini V KaushikSuresh T Mathews

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