Plasma amino acids and glucose levels in the rat fetus and dam after chronic maternal alcohol consumption

Biology of the Neonate
S M MarquisM Lee

Abstract

To evaluate the effect of chronic maternal alcohol consumption on plasma amino acid and glucose levels in both the fetus and the mother, female Sprague-Dawley rats were divided into 3 dietary treatment groups. Group 1 (alcohol) was fed ad libitum a stock diet plus 20% alcohol in drinking water for at least 4 weeks before mating and 30% alcohol during gestation. Group 2 was pair-fed the stock diet plus corn starch calorically equivalent to the amount of alcohol consumed by group 1 animals. Group 3 (control) received the stock diet and water ad libitum. On day 21 of gestation the fetuses of alcohol-treated dams weighed significantly less than those of the control and pair-fed groups. Fetal plasma glucose levels were significantly lower in the alcohol group when compared to those of the pair-fed and control groups, while the maternal glucose levels were similar in all three treatment groups. Plasma amino acid concentrations showed no corresponding trends in mother and fetus. Only proline was significantly reduced and alpha-amino-n-butyric acid elevated in the alcohol-treated dams when compared to the pair-fed and control rats. In the fetal plasma, only aspartic acid was significantly lower in the alcohol group when compared to the...Continue Reading

Citations

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