Mar 28, 2012

Plasma amyloid-β as a predictor of dementia and cognitive decline: a systematic review and meta-analysis

Archives of Neurology
Alain KoyamaFrancine Grodstein


Preclinical prediction of Alzheimer disease (AD) is important and critical to effective intervention. Plasma levels of amyloid-β (Aβ) peptides have been a principal focus of the growing literature on blood-based biomarkers, but studies to date have varied in design, assay methods, and sample size, making it difficult to readily interpret the overall data. To conduct a systematic review and meta-analysis of relevant prospective studies to determine whether plasma amyloid-β levels may predict development of dementia, AD, and cognitive decline. We searched prospective studies published between 1995 and 2011 indexed in the MEDLINE, EMBASE, and PsycINFO databases. Selected studies included those measuring at least 1 relevant plasma amyloid-β species (Aβ(40), Aβ(42), or Aβ(42):Aβ(40) ratio) and reporting an effect estimate for dementia, AD, or cognitive change. Using a standardized extraction form, appropriate study parameters on subject information, exposure, and outcome were extracted. Random effects models were used to generate summary risk ratios and 95% confidence intervals comparing the bottom vs top quantiles for each plasma measure. Thirteen studies with a total of 10 303 subjects met inclusion criteria for meta-analysis. Low...Continue Reading

  • References17
  • Citations50

Mentioned in this Paper

Senile Paranoid Dementia
Familial Alzheimer Disease (FAD)
Pathogenic Aspects
Meta-Analysis (Publications)
APP protein, human
Cerebrospinal Fluid
Alzheimer's Disease
Body Mass Index Procedure
Amyloid Deposition

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