Sep 10, 1976

Plasma and brain amino acids in fulminant hepatic failure and their relationship to hepatic encephalopathy

European Journal of Clinical Investigation
C O RecordR Williams

Abstract

Amino acid concentrations were determined in plasma, whole blood, cerebrospinal fluid and brain tissue of 45 patients with grade 3 or 4 coma due to fulminant hepatic failure. The concentration of 15 of the 19 amino acids determined were significantly increased in blood and the increases were greatest for the amino acids concerned with neurotransmitter metabolism. There was no correlation, however, between the plasma concentration of these amino acids and changes in the grade of hepatic coma. The plasma concentrations of the branched chain amino acids were normal except in those patients who subsequently recovered in whom levels were slightly decreased. Phenylalanine- tyrosine and methionine were among the 15 out of 18 amino acids which were significantly increased in cerebrospinal fluid and among the 15 out of 21 amino acids which were significantly increased in the brain. The increase in tryptophan was associated with a significant elevation in brain 5-hydroxyindoleacetic acid concentration suggesting an increase in 5-hydroxytryptamine turnover in hepatic coma. Brain to plasma ratios of most amino acids in hepatic coma patients were similar to control subjects suggesting that plasma concentration is the main factor controlling...Continue Reading

  • References19
  • Citations144

Citations

Mentioned in this Paper

Brain
Hepatic Encephalopathy
PMS-Tryptophan
Liver Failure, Acute
Neurohormones
Fulminant Hepatic Failure With Cerebral Edema
COMA

About this Paper

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