PMID: 8606288Mar 1, 1996Paper

Plasma and cardiac tissue atrial and brain natriuretic peptides in experimental heart failure

Journal of the American College of Cardiology
G W MoeP W Armstrong

Abstract

This study evaluated the role of changes in heart rate, cardiac filling pressures and cardiac tissue atrial and brain natriuretic peptides in the modulation of their plasma levels in a model of heart failure. Atrial and brain natriuretic peptides constitute a dual natriuretic peptide system that regulates circulatory homeostasis. The effects of 1) acute ventricular pacing, 2) acute volume expansion, and 3) volume expansion after 1 week of continuous pacing on plasma atrial and brain natriuretic peptide levels were compared in eight dogs. Atrial and ventricular tissue levels of the peptides were examined in 5 normal dogs (control group), 21 dogs paced for 1 week (group 1) and 10 dogs paced for 3 weeks (group 2). Both acute pacing and volume expansion increased plasma atrial natriuretic peptide levels (from 53 +/- 41 to 263 +/- 143 pg/ml [mean +/- SD], p < 0.01, and from 38 +/- 23 to 405 +/- 221 pg/ml, p < 0.001, respectively). After 1 week, there was a marked increase in plasma levels of atrial natriuretic peptide, but the level did not increase further with volume expansion (from 535 +/- 144 to 448 +/- 140 pg/ml, p = 0.72). By contrast, plasma brain natriuretic peptide levels increased only modestly with acute pacing (from 12 +...Continue Reading

References

Sep 13, 1990·The New England Journal of Medicine·M MukoyamaH Imura
Apr 1, 1990·Endocrinology·Y OgawaM Jougasaki
Jan 1, 1989·The Journal of Clinical Investigation·Y SaitoT Yamada
Jan 31, 1989·Biochemical and Biophysical Research Communications·Y SaitoN Minamino
Jul 1, 1986·Journal of the American College of Cardiology·R J RodehefferT Inagami
Mar 3, 1988·Nature·T SudohH Matsuo
May 20, 1988·European Journal of Pharmacology·H ItohH Imura
May 1, 1986·Circulation Research·B J Ballermann, B M Brenner
Oct 3, 1985·The New England Journal of Medicine·H NakaokaT Yamaji
Jun 1, 1971·American Heart Journal·H N ColemanE Braunwald
Sep 1, 1993·Circulation·C M WeiJ C Burnett
Sep 1, 1993·Journal of the American College of Cardiology·G W MoeP W Armstrong

❮ Previous
Next ❯

Citations

Aug 24, 1999·Pacing and Clinical Electrophysiology : PACE·K YlitaloK Peuhkurinen
Nov 5, 2011·Heart Failure Reviews·Pedram KazemianBodh I Jugdutt
Aug 13, 2011·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Heidi B KellihanRebecca L Stepien
Mar 21, 2009·Clinical Cardiology·Masazumi WatanabeTsuyoshi Hachimaru
Jun 24, 1999·The Journal of Veterinary Medical Science·K AsanoT Fujinaga
Oct 20, 1999·Journal of Molecular and Cellular Cardiology·X SuL J Dell'Italia
Sep 19, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G M BialikD Lewinson
Jun 19, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Gordon W MoeQingping Feng
Jun 12, 2004·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·Bernard LétéPascale Colé
May 23, 2002·Journal of Hypertension·Hans Peter Brunner-La RoccaMurray D Esler
Feb 14, 2012·Language Acquisition·Iris BerentTracy Lennertz
Mar 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·William S BradhamFrancis G Spinale

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.