PMID: 7091608Mar 1, 1982

Plasma and cerebrospinal fluid barbiturate levels during prolonged continuous thiopentone infusion

Anaesthesia
I L AireyJ C Stoddart

Abstract

During an infusion of thiopentone to control status epilepticus secondary to hypoxic brain damage, thiopentone and pentobarbitone levels were measured in the serum and cerebrospinal fluid (CSF). Pentobarbitone was found to be present in the serum between 7.8 and 11.1% of the thiopentone levels. There was a prompt response in serum levels of thiopentone to changes in the infusion rate. The CSF thiopentone varied between 15 and 40% of the serum levels. The CSF anticonvulsant threshold for thiopentone for this patient was between 5 and 15 mg/litre.

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Citations

Nov 17, 1995·Journal of Chromatography. B, Biomedical Applications·J L HuangC C Duke
May 1, 1995·Disease-a-month : DM·R C BoneM Guerrero
Jul 1, 1993·European Journal of Drug Metabolism and Pharmacokinetics·P Le CorreR Le Verge
May 1, 1993·Journal of Pharmaceutical Sciences·H RussoH Maillols
Nov 18, 2005·Neuroscience·Tateo OhtsukaTomio Andoh
Nov 14, 1998·Glia·R A Swanson, L L Seid
Apr 1, 1986·Drug Intelligence & Clinical Pharmacy·W A WatsonJ D Puckett
Dec 1, 1985·Anaesthesia·H N ChanM D Boyd

Related Concepts

Drowning
Parenteral Infusion
Diabutal
Simple Partial Status Epilepticus
Sodipental

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