Plasma and plasma derivatives in therapeutic plasmapheresis

Transfusion
Bruce C McLeod

Abstract

In therapeutic plasmapheresis, patient plasma is withdrawn and a colloid replacement solution is infused in its place. A 4% to 5% human serum albumin solution in saline is the preferred replacement solution in most instances, even though this practice causes transient mild deficiencies of most plasma proteins. Albumin solutions are pasteurized for viral inactivation, are very unlikely to cause a febrile or allergic reaction, and are convenient to store and administer. Single-donor plasma must be type specific, which requires advance knowledge of patient blood type, and must be ordered and usually thawed before use. It also carries a higher risk of reactions. On the plus side, it replaces all plasma constituents and is appropriate for patients with thrombotic thrombocytopenic purpura or an existing coagulopathy. Neither cryosupernatant plasma, which is relatively deficient in the proteins in cryoprecipitate, nor plasma derived from pools that have been virally inactivated with detergents and organic solvents has been shown to produce better outcomes than fresh frozen plasma for any indication.

References

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Citations

Dec 3, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Nilay Sengul SamanciSavas Ozturk
Nov 5, 2014·Acta Clinica Belgica·Daan Dierickx, E Macken
Aug 16, 2016·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Satoko MiyamotoTomokazu Okado
Jul 1, 2017·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Atsushi OhkuboTatemitsu Rai
Dec 17, 2014·Cancer Control : Journal of the Moffitt Cancer Center·Laura S Connelly-Smith, Michael L Linenberger
Jul 4, 2018·Endocrine·Ilgin Yildirim SimsirAhmet Gokhan Ozgen
Dec 19, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Vandita DwivediMichal Sharon
Feb 12, 2021·Journal of Veterinary Internal Medicine·Thierry FranceyAriane Schweighauser
May 11, 2021·Nano Today·Dalila IannottaJoy Wolfram
Jan 15, 2020·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Nina WorelErwin Strasser

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