PMID: 7371704Feb 1, 1980Paper

Plasma and salivary pharmacokinetics of dapsone estimated by a thin layer chromatographic method

European Journal of Clinical Pharmacology
R A Ahmad, H J Rogers

Abstract

A high performance thin layer chromatographic assay for dapsone is described with a minimum level of detection of 20 ng ml-1 which is suitable for the study of dapsone pharmacokinetics in plasma and saliva. 100 mg dapsone was administered orally to seven normal adult volunteers, the mean plasma pharmacokinetic parameters were: alpha = 0.23 h-1; beta = 0.0236 h-1, and t1/2 beta = 30.2 h. Dapsone is also eliminated into the saliva and the t1/2 may be determined via its estimation in saliva. It is 73% bound to plasma protein and the saliva/plasma concentration ratio was found to be 27%. In two subjects the free plasma dapsone concentration was identical to the simultaneous salivary dapsone concentration. Therefore the salivary dapsone concentration is a measure of the free plasma fraction of dapsone. Saliva/plasma dapsone concentration ratios show no time or concentration dependence and little inter-individual variation but are unsuitable for acetylator phenotype determination because monoacetyldapsone is not eliminated in the saliva.

References

Jul 1, 1976·The Journal of Pharmacy and Pharmacology·K WilliamsR Best
Jan 1, 1978·Clinical Pharmacokinetics·M Danhof, D D Breimer
Jan 1, 1978·The Western Journal of Medicine·D K Oxley, C L Fischer
Sep 1, 1976·Clinical Pharmacology and Therapeutics·R L GaleazziL B Sheiner
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Citations

Sep 5, 1991·The New England Journal of Medicine·C E MetrokaD P Jacobus
Sep 1, 1994·Antimicrobial Agents and Chemotherapy·G A BreenS Forlenza
Jan 1, 1988·British Journal of Clinical Pharmacology·Y HoraiT Ishizaki
Nov 1, 1980·British Journal of Clinical Pharmacology·R A Ahmad, H J Rogers
Apr 1, 1988·British Journal of Clinical Pharmacology·Y Horai, T Ishizaki
Jul 1, 1981·British Journal of Clinical Pharmacology·R A AhmadP Wright
Jan 1, 1983·The British Journal of Dermatology·A F SwainL Fry
Apr 1, 1984·British Journal of Clinical Pharmacology·P A PhilipH J Rogers
Jan 13, 2001·Dermatologic Clinics·U Paniker, N Levine
May 1, 1982·British Journal of Clinical Pharmacology·M J VandenburgR A Ahmad
Mar 4, 2014·Nihon Hansenbyō Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association·Masamichi GotoUNKNOWN Japanese Leprosy Association
Oct 1, 1986·British Journal of Clinical Pharmacology·F A Pieters, J Zuidema
Mar 1, 1982·Pharmazie in unserer Zeit·B Mühlenbruch
Jun 1, 1992·The Annals of Pharmacotherapy·M Gibaldi
Aug 1, 1981·The Journal of Pharmacy and Pharmacology·R A Ahmad, H J Rogers
Aug 1, 1991·Journal of Clinical Pharmacy and Therapeutics·M A AbuirjeieN M Rawashdeh

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