Plasma and Serum Metabolite Association Networks: Comparability within and between Studies Using NMR and MS Profiling

Journal of Proteome Research
Maria Suarez-DiezEdoardo Saccenti

Abstract

Blood is one of the most used biofluids in metabolomics studies, and the serum and plasma fractions are routinely used as a proxy for blood itself. Here we investigated the association networks of an array of 29 metabolites identified and quantified via NMR in the plasma and serum samples of two cohorts of ∼1000 healthy blood donors each. A second study of 377 individuals was used to extract plasma and serum samples from the same individual on which a set of 122 metabolites were detected and quantified using FIA-MS/MS. Four different inference algorithms (ARANCE, CLR, CORR, and PCLRC) were used to obtain consensus networks. The plasma and serum networks obtained from different studies showed different topological properties with the serum network being more connected than the plasma network. On a global level, metabolite association networks from plasma and serum fractions obtained from the same blood sample of healthy people show similar topologies, and at a local level, some differences arise like in the case of amino acids.

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Citations

Mar 6, 2018·Metabolomics : Official Journal of the Metabolomic Society·Antonio RosatoEdoardo Saccenti
Oct 13, 2018·Critical Reviews in Clinical Laboratory Sciences·Gabriel Lima-OliveiraGian Cesare Guidi
Jul 13, 2018·Angewandte Chemie·Alessia VignoliClaudio Luchinat
May 30, 2019·Biomarkers in Medicine·Shiva Kalantari, Mohsen Nafar
Apr 25, 2020·Journal of Human Hypertension·Jikang ShiYawen Liu
Jan 8, 2021·Journal of Translational Medicine·Mariola OlkowiczRyszard T Smolenski
Mar 7, 2021·International Journal of Molecular Sciences·Jing HuangAnuradha Ramoji
Jun 13, 2021·Communications Biology·N Mota-MartorellR Pamplona
Jun 17, 2021·GeroScience·Paul S Brookes, Ana Gabriela Jimenez
Jul 27, 2021·Frontiers in Molecular Biosciences·Jennie Sotelo-OrozcoCarolyn M Slupsky
Nov 2, 2017·Journal of Proteome Research·Alessia VignoliEdoardo Saccenti
Sep 16, 2019·Computers in Biology and Medicine·Jai Woo LeeJiang Gui

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR
PCA

Software Mentioned

ARANCE
MetaboAnalyst
AMIX
PCRLC
R package “ minet ”
ARACNE

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