PMID: 10651201Jan 29, 2000Paper

Plasma and urinary levels of heart fatty acid-binding protein in patients undergoing cardiac surgery

Japanese Circulation Journal
N HayashidaS Aoyagi

Abstract

To evaluate the clinical significance of the plasma and urinary levels of heart fatty acid-binding protein (H-FABP) in patients undergoing cardiac surgery, a prospective study was conducted. Ten patients undergoing coronary artery bypass grafting were enrolled. Blood samples for determination of plasma H-FABP (pH-FABP), the MB isoenzyme of creatine kinase (CK-MB) and troponin-T (TnT), and urine samples for determination of urinary H-FABP (uH-FABP) were collected serially. None of the patients had perioperative myocardial infarction. The time to reach the peak level after aortic declamping was significantly (p<0.05) shorter for pH-FABP (1.4+/-0.5 h) than for CK-MB (2.5+/-0.5 h), TnT (6.6+/-1.3 h) or uH-FABP (3.0+/-0.6 h). Peak levels of pH-FABP correlated with those of CK-MB (r = 0.51, p = 0.04), TnT (r = 0.60, p = 0.03) and uH-FABP (r = 0.61, p = 0.03), and peak levels of uH-FABP correlated with CK-MB (r = 0.57, p = 0.04). Postoperative uH-FABP levels correlated inversely with the left ventricular stroke work index (r = -0.63, p = 0.04). This study demonstrated that H-FABP appears rapidly in plasma after reperfusion and reaches its peak earlier than other available biochemical markers; it appears also in urine and the levels co...Continue Reading

References

Jan 1, 1979·Annual Review of Medicine·C L Hall, J Hardwicke
Jun 1, 1982·Circulation·F J KlockeM Reichlin
Mar 1, 1997·The Annals of Thoracic Surgery·I BirdiA J Bryan
Feb 4, 1999·The Annals of Thoracic Surgery·F F ImmerT P Carrel
Dec 10, 1999·The Annals of Thoracic Surgery·N HayashidaS Aoyagi

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Citations

Mar 19, 2004·QJM : Monthly Journal of the Association of Physicians·H A Alhadi, K A A Fox
Nov 7, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Ocal Berkan, Mansur Sagban
Jan 18, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maurice M A L PelsersJan F C Glatz
Sep 18, 2007·Journal of the Neurological Sciences·Kenji Wada-IsoeKenji Nakashima
Jun 7, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hong LiuHua Jing
Jul 23, 2020·Annals of Medicine·Harsh GoelGregory Y H Lip
Jun 26, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Eftihia SbarouniVassilis Voudris
Apr 21, 2004·British Journal of Anaesthesia·M KempJ Hooper

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