PMID: 8587155Oct 1, 1995Paper

Plasma and urine disposition and dose proportionality of ceftiofur and metabolites in dogs after subcutaneous administration of ceftiofur sodium

Journal of Veterinary Pharmacology and Therapeutics
S A BrownT F Flook

Abstract

Nine male dogs (10.3-13.5 kg body weight) were randomly assigned to three groups of three dogs each and administered ceftiofur sodium subcutaneously as a single dose of 0.22, 2.2, or 4.4 mg ceftiofur free acid equivalents/kg body weight. Plasma and urine samples were collected serially for 72 h and assayed for ceftiofur and metabolites (derivatized to desfuroylceftiofur acetamide) using high-performance liquid chromatography. Urine concentrations remained above the MIC90 for Escherichia coli (4.0 micrograms/mL) and Proteus mirabilis (1.0 micrograms/mL) for over 24 h after doses of 2.2 mg/kg (8.1 micrograms/mL) and 4.4 mg/kg (29.6 micrograms/mL), the interval between treatments for ceftiofur sodium in dogs, whereas urine concentrations 24 h after dosing at 0.22 mg/kg (0.1 mg/Ib) were below the MIC90 for E. coli and P. mirabilis (0.6 microgram/mL). Plasma concentrations were dose-proportional, with peak concentrations of 1.66 +/- 0.0990 micrograms/mL, 8.91 +/- 6.42 micrograms/mL, and 26.7 +/- 1.07 micrograms/mL after doses of 0.22, 2.2, and 4.4 mg/kg, respectively. The area under the plasma concentration versus time curve, when normalized to dose, was similar across all dosage groups.

References

Apr 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·K YamaokaT Uno

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Citations

May 23, 1998·Journal of Veterinary Pharmacology and Therapeutics·L TellA Craigmill
Mar 5, 2004·Journal of Veterinary Pharmacology and Therapeutics·Mark L DrewColin Mackintosh
Nov 7, 2006·Journal of Veterinary Pharmacology and Therapeutics·M R StegemannS Blanchflower
Apr 29, 1998·The Veterinary Clinics of North America. Small Animal Practice·M G Papich
Nov 27, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wandee RungseevijitprapaRoland Bodmeier
Nov 5, 2003·American Journal of Veterinary Research·Keith G BensonArthur L Craigmill
Nov 5, 2019·Frontiers in Veterinary Science·Jianzhong WangXingyuan Cao
Apr 14, 2020·Journal of Veterinary Pharmacology and Therapeutics·Fang YangMei Zhang

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