Plasma androgen responce to hCG stimulation in prepubertal boys with hypospadias and cryptorchidism

The Journal of Clinical Endocrinology and Metabolism
P C WalshP K Siiteri


Serum levels of testosterone, androstenedione and dehydroepiandrosterone were measured before and after 5 days of treatment with hCG (2000 IU/d) in 36 prepubertal boys with cryptorchidism and 11 with hypospadias in order to determine whether a defect in androgen synthesis could be a common cause for these disorders. Baseline and stimulated levels of testosterone, androstenedione and dehydroepiandrosterone were similar in patients with unilateral cryptorchidism, monorchism and hypospadias; baseline and stimulated levels of testosterone were lower in boys with bilateral cryptorchidism. Testosterone levels did not correlate with either the anatomical location of the testis in patients with unilateral cryptorchidism or with the site of the urethra in boys with hypospadias. Seven of 36 patients with cryptorchidism had a positive family history of a similar disorder; testosterone levels were similar in patients with and without a family history. It is concluded: 1) in all patients studied, the gonadotropin dependent phase of testosterone production is present; 2) hCG stimulation cannot detect unilateral Leydig cell dysfunction; and 3) in familial cases of cryptorchidism, some factor other than an abnormality in androgen synthesis may...Continue Reading


Jan 1, 1987·European Journal of Pediatrics·J Rajfer
Jan 1, 1992·International Urology and Nephrology·M MerkszL Pirót
Jan 1, 1996·International Urology and Nephrology·M MiuraY Onnmura
May 1, 1977·Journal of Steroid Biochemistry·R B JaffeC Korenbrot
Jan 1, 1980·Pharmacology & Therapeutics·G Telegdy
Jan 24, 1980·The New England Journal of Medicine·J E Griffin, J D Wilson
Dec 1, 1981·Clinical Endocrinology·T PasqualiniM A Rivarla
Sep 1, 1986·Clinical Endocrinology·H E Kulin, S J Santner
Mar 21, 2001·The Journal of Urology·A L BoehmerS L Drop
Mar 1, 1982·Clinics in Endocrinology and Metabolism·M O Savage
Jan 1, 2006·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Junko MiyamotoYukihiro Hasegawa
Sep 1, 1983·Acta Psychiatrica Scandinavica·R BergG Aström
Oct 1, 1983·International Journal of Andrology·G Läckgren, A A Berg
May 1, 1985·American Journal of Medical Genetics·M FrydmanH A Cohen
Jul 1, 1978·The Journal of Urology·P C WalshW E Goodwin
Mar 1, 1986·The Journal of Urology·H ShimaM Fukuchi
May 24, 2001·The Journal of Urology·I M McAleer, G W Kaplan
Sep 1, 1984·Journal of Andrology·C EilD L Loriaux
Jul 1, 1979·The Journal of Urology·F Hinman
Dec 1, 1977·The Journal of Urology·J Rajfer, P C Walsh
Jan 1, 1988·Pediatric Annals·M A KoyleR M Ehrlich
Oct 1, 1980·The Journal of Urology·F F MarshallR D Jeffs
Aug 1, 1990·The Journal of Urology·J P GearhartG D Berkovitz
Sep 1, 1984·The Journal of Urology·F F BartoneC F Firlit
Sep 1, 1984·The Journal of Urology·K NonomuraT Koyanagi
Dec 1, 1976·The Journal of Urology·J Rajfer, P C Walsh

Related Concepts

Androgen Effect
Unilateral Cryptorchidism
Prasterone, 3 alpha-Isomer

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.