PMID: 589072Nov 5, 1977

Plasma androstenedione and oestrone levels in normal and osteoporotic postmenopausal women

British Medical Journal
D H MarshallB E Nordin

Abstract

Plasma androstenedione and oestrone concentrations were measured in 72 postmenopasual women. The women included some who had undergone oophorectomy, some with osteoporosis, and normal controls; they were matched for years since menopause. Both hormone concentrations were significantly reduced in the women with osteoporosis. The women who had undergone oophorectomy had hormone concentrations intermediate between the normal and osteoporotic values. Oestrogen deficiency secondary to low androstenedione levels is a major risk factor in postmenopausal osteoporosis, and may be caused by failure of ovarian stromal androgen secretion or some abnormality in the pituitary-adrenal axis.

References

Jan 1, 1976·Clinical Endocrinology·B E NordinD A Williams
Jul 1, 1973·Clinics in Endocrinology and Metabolism·J C GallagherB E Nordin
Mar 1, 1974·The Journal of Clinical Endocrinology and Metabolism·D L HemsellP C MacDonald

Citations

Jun 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H OhtaS Nozawa
Jun 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Goulding, E Gold
Apr 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S K JassalS L Edelstein
Mar 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M SzathmáriI Holló
Oct 1, 1990·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M A KotowiczB L Riggs
Oct 1, 1998·Environmental Health and Preventive Medicine·T Akatsu
Jul 1, 1979·Journal of Steroid Biochemistry·R CrillyB E Nordin
Jun 1, 1996·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·M Lanzetta, W A Morrison
Feb 1, 1988·Baillière's Clinical Endocrinology and Metabolism·J C Stevenson
Feb 16, 1980·British Medical Journal·B E NordinM Simpson
Mar 28, 1987·British Medical Journal·J P DevogelaerC Nagant de Deuxchaisnes
Jul 18, 1987·British Medical Journal·J P DevogelaerC Nagant de Deuxchaisnes
Nov 1, 1992·Postgraduate Medical Journal·S MurphyJ E Compston
Nov 1, 1987·The Journal of Clinical Investigation·C SlemendaC C Johnston
Sep 8, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R D ChapurlatP D Delmas
Jun 1, 1987·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S DeutschA Frank
Jun 1, 1990·Maturitas·S RozenbergC Robyn
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Jane A CauleyRobert Boudreau
Jun 24, 1978·Lancet·W G McBride
Feb 1, 1979·Clinical Endocrinology·R CrillyB E Nordin
Jul 1, 1995·Clinical Endocrinology·H U SchweikertG Romalo
Jul 1, 1978·Clinical Endocrinology·A Vermeulen, L Verdonck
Mar 1, 1985·British Journal of Obstetrics and Gynaecology·J JensenC Christiansen
Jun 17, 1998·The Journal of Clinical Endocrinology and Metabolism·H M HeshmatiB L Riggs
Mar 20, 1999·The Journal of Clinical Endocrinology and Metabolism·C MassafraF Bagnoli
Jul 25, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B L RiggsL J Melton
Jan 14, 2000·The Journal of Clinical Endocrinology and Metabolism·E Barrett-ConnorD J Sartoris
Feb 1, 1982·Journal of the American Geriatrics Society·L G Raisz
May 1, 1985·Acta Radiologica. Oncology·H E NielsenC C Gadeberg

Related Concepts

Androstenedione
Castration
Unigen
Menopause
Post-Traumatic Osteoporosis

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.