Plasma angiogenesis and oxidative stress markers in patients with diabetic retinopathy.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Bhaskar GaonkarMuralidhar Varma

Abstract

Background: Neovascularization in the retina and hyperglycaemia-induced oxidative stress are implicated in the pathogenesis of diabetic retinopathy (DR). In this study, we hypothesized that the plasma angiogenic and oxidative stress markers associated with these derangements could aid in the screening of diabetic patients who are at an increased risk of developing retinopathy.Methods: This study included normal (n = 148), type2 diabetes without retinopathy (DNR; n = 148), proliferative DR (PDR; n = 74) and non-PDR (NPDR; n = 148) subjects. Plasma concentrations of vascular endothelial growth factor-A (VEGF-A), hypoxia-inducible factor-1α (HIF-1α), matrix metalloproteinase-9 (MMP-9), pigment epithelium-derived factor (PEDF), nitric oxide (NO), soluble receptors for advanced glycation end products (sRAGE), malondialdehyde (MDA) and protein thiols were estimated.Results: A statistically significant increase was observed in the plasma concentrations of pro-angiogenic factors and markers of oxidative stress in both retinopathy groups. By contrast, the concentrations of anti-angiogenic factors and antioxidants were decreased significantly in these groups. Receiver operating characteristic analysis indicated that the plasma thresholds...Continue Reading

References

Nov 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Satoh
Sep 6, 2003·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Serap OzdenGill Güner
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Colomba FalconeDiego Geroldi
Jan 24, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·S JacqueminetJ-L Beaudeux
Oct 3, 2006·Japanese Journal of Ophthalmology·Naohiro IzumiAkitoshi Yoshida
Jan 11, 2007·The Journal of Clinical Endocrinology and Metabolism·Nahoko OgataMiyo Matsumura
Apr 24, 2012·Expert Opinion on Investigational Drugs·Renu A KowluruJulia M Santos
Dec 5, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·L Z HengP G Hykin
Mar 1, 2012·Journal of Ocular Biology, Diseases, and Informatics·Ghulam Mohammad, Mohammad Mairaj Siddiquei
Jun 10, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tapan Behl, Anita Kotwani
Jul 25, 2017·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Randa S EshaqNorman R Harris

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.