Mar 1, 1976

Plasma angiotensin II levels and water intake following beta-adrenergic stimulation, hypovolemia, cellular dehydration and water deprivation

Pharmacology, Biochemistry, and Behavior
A E AbdelaalG J Mogenson


A comparison of the effects of extracellular and intracellular thirst stimuli on plasma levels of angiotensin II was made in rats. The administration of polyethylene glycol and isoproterenol elicited a strong drinking response and resulted in a significant increase in plasma angiotensin II. There was a significant correlation between the volume of water intake and plasma angiotensin II levels following the injection of polyethylene glycol but not following isoproterenol. Drinking was also elicited by the administration of hypertonic saline but there was no increase in plasma angiotensin II. The results suggest that endogenously released angiotensin II contributes to extracellular thirst but not to intracellular thirst.

Mentioned in this Paper

Fresh Frozen Plasma
Experimental Water Deprivation
Adrenergic beta-Agonists
Hypertonic Solutions
Angiotensin II, Val(5)-
Sodium Chloride, (24)NaCl

About this Paper

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