Plasma antioxidant enzymes and lipoperoxidation status in children with Down syndrome

Clinical Biochemistry
Jingyi HeCui Song

Abstract

Oxidative stress (OS) may play a critical role in cell aging and neurologic disorders that are often seen in Down syndrome (DS) patients. The aim of this study was to determine the antioxidant enzyme level and lipoperoxidation status in blood from DS children. In a cross-sectional study, we recruited a total of 36 DS children and 40 healthy controls (HCs). All subjects were free of infection according to the C reactive protein (CRP) value and routine peripheral blood profile. The activities of total superoxide dismutases (SODs), extracellular glutathione peroxidase (GPx3),malondialdehyde (MDA) and nitric oxide synthase (NOS) concentrations in peripheral blood were measured by spectrophotometric methods. The relationship of SOD and GPx3 was analyzed in the two groups. The two groups were similar with respect to age, gender and peripheral blood profiles. The total SOD activity was significantly increased, while the GPx3 activity was significantly reduced in the DS group compared to the HCs (p=0.000, p=0.033 respectively). The MDA level was higher in DS children (p=0.013). There was no significant difference in NOS between DS and HCs (p=0.708). A significant negative correlation between GPx3 and SOD activity was identified in DS (...Continue Reading

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Citations

Jan 20, 2018·Journal of Intellectual Disability Research : JIDR·S MantiV Salpietro
Jan 30, 2019·Oxidative Medicine and Cellular Longevity·Nicola LaforgiaNicoletta Resta
Aug 8, 2019·Developmental Neurobiology·Melissa E Petersen, Sid E O'Bryant
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Arianna Carolina RosaFranco Dosio
Jul 15, 2021·Disease Markers·Dominik SzwajgierWioletta Żukiewicz-Sobczak

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