Plasma antiretroviral levels in children with human immunodeficiency virus infection. Influence of sex and age

Enfermedades infecciosas y microbiología clínica
Ana Pilar Nso-RocaMaría Isabel de José

Abstract

Pharmacologic studies have shown a relationship between plasma antiretroviral levels and toxicity/viral activity. Nevertheless, pharmacokinetic and pharmacodynamic data are inconsistent and limited in HIV-infected children. An analysis was performed of plasma antiretroviral concentrations in clinical practice and their influence on therapy efficacy in HIV-infected children. Observational, prospective, multicenter study, including HIV-infected children followed up at 5 reference hospitals between March 2006 and June 2008. Pre-dose plasma antiretroviral levels were determined and the relationships with various clinical and analytical variables were investigated. A total of 129 patients were included, and 41.3% had antiretroviral plasma levels outside the established range. No differences were found between sexes. Children younger than 1 year had a higher rate of suboptimal levels and higher viral load than the remaining children. Antiretroviral plasma concentrations are more frequently suboptimal in children younger than 1 year. This finding is related with greater viral failure and implies a considerable challenge in this population, which requires very long-term treatment.

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Citations

Jul 16, 2011·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·C Valdivia VadellC Figueras Nadal
Jul 17, 2012·Pharmacology·Josilene Chaves Ruela CorrêaHérida Regina Nunes Salgado

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