Plasma antithrombin III and protein C levels in early recognition of late-onset sepsis in newborns.

European Journal of Pediatrics
Ryszard LauterbachKrzysztof Rytlewski

Abstract

The aim of this prospective, observational study was to establish the prognostic values of plasma antithrombin III (ATIII) and protein C (PC) functional levels, determined in 150 neonates with suspected late-onset sepsis. Both the ATIII and PC concentrations were significantly lower in neonates with sepsis, either confirmed or not confirmed by blood culture, than data obtained in infants with excluded disease. The lowest values of plasma ATIII and PC were observed in neonates who had died in the course of sepsis. The differences between survivors and non-survivors were statistically significant (respectively, for ATIII P=0.003 and for PC P=0.00002). A highly statistically significant correlation (P=0.0016) between plasma PC functional level and risk of death was found in patients with sepsis. However, plasma ATIII concentration, evaluated in the same group of patients, did not correlate with the occurrence of death. We concluded that the measurement of plasma ATIII and, especially, PC levels may facilitate the recognition of sepsis and, with respect to PC, may have a prognostic value. Plasma PC functional concentration below 10% might be the indication for supplementation of PC concentrate.

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Citations

Nov 20, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Amal El BeshlawyMohamed Salah Eldin Mohamed Abdel Kader
Jun 24, 2010·Clinics in Perinatology·James L Wynn, Ofer Levy
Jun 24, 2010·Clinics in Perinatology·James L Wynn, Hector R Wong
Jul 1, 2008·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Vidula Vachharajani
Jul 17, 2009·Acta Paediatrica·Doris FischerAlex Veldman
Sep 1, 2016·Transfusion Medicine Reviews·Rowena C Punzalan, Jerome L Gottschall
Apr 2, 2019·Fetal and Pediatric Pathology·Nashwa SamraMohammed Eid
Jun 3, 2016·The Pediatric Infectious Disease Journal·Ryszard LauterbachRenata Radziszewska
May 31, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Jun-Hua TangPeng-Fei Zou
Nov 18, 2018·Annals of Intensive Care·Christian NiederwangerPetra Innerhofer
May 28, 2019·Journal of Clinical Medicine·Toshiaki IbaTheodore E Warkentin
May 26, 2020·Kidney & Blood Pressure Research·Alessandra F PernaDiego Ingrosso

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