PMID: 15247557Jul 13, 2004Paper

Plasma ascorbate deficiency is associated with impaired reduction of sulfamethoxazole-nitroso in HIV infection

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Lauren A TrepanierFrank M Graziano

Abstract

The objective of these studies was to determine the role of ascorbate deficiency in HIV infection in the defective detoxification of sulfamethoxazole-nitroso, the metabolite thought to mediate sulfonamide hypersensitivity reactions. Fifty-one HIV-infected patients and 26 healthy volunteers were evaluated. Vitamin supplementation histories were obtained, and blood samples were collected for determination of plasma ascorbate, dehydroascorbate, and cysteine concentrations, erythrocyte glutathione concentrations, and plasma reduction of sulfamethoxazole-nitroso in vitro. Plasma ascorbate concentrations were significantly lower in HIV-positive patients not taking vitamin supplements (29.5 +/- 22.3 microM) than in healthy subjects (54.8 +/- 22.3 microM; P = 0.0005) and patients taking 500-1000 mg of ascorbate daily (82.5 +/- 26.3 microM; P < 0.0001). Plasma ascorbate deficiency was strongly correlated with impaired reduction of sulfamethoxazole-nitroso to its hydroxylamine (r = 0.60, P < 0.0001), and during in vitro reduction, the loss of plasma ascorbate was strongly associated with the amount of nitroso reduced (r = 0.70, P < 0.0001). Ascorbate added ex vivo normalized this reduction pathway. Erythrocyte glutathione concentrations ...Continue Reading

References

Feb 1, 1979·Chemico-biological Interactions·P Eyer
Apr 11, 1992·Lancet·F J StaalL A Herzenberg
May 1, 1992·Clinical Pharmacology and Therapeutics·A E Cribb, S P Spielberg
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S HarakehL Pauling
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J MãrtenssonJ Mrtensson
Jan 1, 1990·Annals of the New York Academy of Sciences·J D BogdenD Louria
Nov 1, 1989·The American Journal of Clinical Nutrition·H E SauberlichJ H Skala
Aug 1, 1986·Annals of Internal Medicine·N H ShearW Kalow
Mar 1, 1982·Reviews of Infectious Diseases·H Jick
Jul 1, 1980·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B DölleH G Neumann
Apr 1, 1995·Seminars in Cell Biology·A M Carr
Jan 6, 1995·Toxicology·M J RiederI A Bird
Aug 1, 1994·British Journal of Clinical Pharmacology·A J van der VenJ W van der Meer
Oct 1, 1994·Free Radical Biology & Medicine·B S WinklerT S Rex
Apr 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P Pertel, R Hirschtick
Jul 1, 1993·The American Journal of Clinical Nutrition·C S JohnstonJ C Srilakshmi
Aug 15, 1993·Archives of Biochemistry and Biophysics·M Nakamura, S Ohtaki
Oct 1, 1993·Clinical and Experimental Immunology·A CarrD A Cooper
Jan 22, 1996·Archives of Internal Medicine·J P IoannidisH S Sacks
Jan 1, 1996·Free Radical Biology & Medicine·J M MayC E Cobb
Apr 11, 1997·The Journal of Biological Chemistry·V H GuaiquilJ C Vera
Jun 1, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·H C BucherM Opravil
Jan 24, 1998·The American Journal of Clinical Nutrition·J P AllardS Walmsley
Dec 22, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·S L WalmsleyO Djurdjev
Apr 27, 1999·British Journal of Pharmacology·D J NaisbittB K Park
May 9, 2000·The American Journal of Clinical Nutrition·K J LentonJ R Wagner
May 16, 2000·European Journal of Clinical Investigation·A TreitingerD S Abdalla
Jul 25, 2000·Journal of Chromatography. a·J C Deutsch
Sep 1, 2000·The American Journal of Clinical Nutrition·J D BogdenD B Louria
Oct 13, 2000·European Journal of Clinical Investigation·F MüllerS S Frøland
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A G Bowie, L A O'Neill
Jan 12, 2001·AIDS Research and Human Retroviruses·D J NaisbittB K Park

❮ Previous
Next ❯

Citations

Jan 16, 2009·Journal of Veterinary Internal Medicine·K R VivianoL A Trepanier
Mar 21, 2012·Journal of Veterinary Internal Medicine·E BranterL A Trepanier
Apr 6, 2006·The AAPS Journal·Joseph P SandersonB Kevin Park
Jan 6, 2009·Journal of the American Veterinary Medical Association·Katherine L Moyer, Lauren A Trepanier
May 1, 2007·Expert Review of Clinical Immunology·Munir PirmohamedB Kevin Park
Mar 21, 2007·Expert Opinion on Drug Safety·Dean J NaisbittB Kevin Park
Oct 19, 2016·Toxicology·Yat Yee WongLauren A Trepanier
Jul 15, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S N LavergneL A Trepanier
Jul 12, 2007·Pharmacogenetics and Genomics·Joseph R KurianLauren A Trepanier
Mar 24, 2005·The Journal of Pharmacology and Experimental Therapeutics·Sanjoy RoychowdhuryCraig K Svensson
Jun 4, 2005·The Journal of Pharmacology and Experimental Therapeutics·Jacqueline ArpGregory A Dekaban
Jun 13, 2017·Pharmacology Research & Perspectives·Yat Yee WongLauren A Trepanier
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph P SandersonB Kevin Park

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.