PMID: 9735917Sep 15, 1998

Plasma aspartate aminotransferase (AST), glutamate dehydrogenase (GLDH) and gamma-glutamyl transpeptidase (GGT) activities in water buffaloes with experimental subclinical fasciolosis

Veterinary Parasitology
Q YangJ González-Gallego


The effect of chronic Fasciola hepatica infection on the activity of plasma aspartate aminotransferase (AST), glutamate dehydrogenase (GLDH) and gamma-glutamyl transpeptidase (GGT) was investigated in water buffaloes dosed daily with 60 F. hepatica metacercariae over 20 days. Experimental fluke infection caused no clinical signs but provoked an increase in plasma level of IgG directed against F. hepatica from 4 weeks after infection. There was a significant increase in plasma AST from 6 weeks post-infection. Maximal values were reached at 14 weeks and remained significantly elevated by 23 weeks. Plasma GLDH was significantly elevated from 6 to 21 weeks post-infection. Significant increases in plasma GGT occurred from 8 to 26 weeks post-infection, reaching maximal values at 15 weeks. This study shows that plasma enzyme activities may be useful in studies of fluke-induced liver damage in water buffaloes.


Nov 1, 1991·Experimental Parasitology·P GonzalezJ Gonzalez
Apr 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A E TufenkjiP Galtier
Jan 1, 1995·Parasitology Research·I FerreJ González-Gallego
Jan 1, 1995·Parasitology Research·I FerreF A Rojo-Vázquez
Oct 1, 1994·Veterinary Parasitology·I FerreF A Rojo-Vázquez
Apr 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H A Benchaoui, Q A McKellar
Mar 1, 1996·Veterinary Parasitology·I FerreJ González-Gallego


Dec 1, 2009·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·S M A AbidiM K Saifullah
Mar 14, 2000·Veterinary Parasitology·S X JiangJ González-Gallego
Nov 3, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·T AlekhovaC Dournon
Nov 15, 2000·Parasitology International·L ChenX Mao
Jun 19, 2010·The Journal of Parasitology·Süleyman Kozat, Vural Denizhan
Jan 13, 2010·Research in Veterinary Science·Antonio H H MinervinoEnrico L Ortolani
Apr 24, 2012·Veterinary Parasitology·F A Rojo-VázquezM Martínez-Valladares
Nov 7, 2008·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Antonio H H MinervinoEnrico L Ortolani
Jul 9, 2020·Veterinary World·Nani Nasreldin, Rania Samir Zaki
Jan 24, 2019·International Journal for Parasitology. Parasites and Wildlife·Ji-Li ZhangJi-Yu Zhang

Related Concepts

Helminth Antibodies
SGOT - Glutamate oxaloacetate transaminase
Fasciola hepatica
Gamma-glutamyl transferase
Glutamate Dehydrogenase

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