Plasma asymmetric dimethylarginine (ADMA), nitrate and the indices of low-density lipoprotein oxidation

Clinica Chimica Acta; International Journal of Clinical Chemistry
Hannu PäiväTerho Lehtimäki

Abstract

Oxidative modification of low-density lipoprotein (LDL) is an important contributor to atherosclerosis. Also, oxidized LDL is suspected to cause accumulation of asymmetric dimethylarginine (ADMA), an endogenous competitive nitric oxide synthase inhibitor, which is suggested to be an independent risk factor for atherosclerosis. This study was performed to evaluate how plasma ADMA is related to plasma nitric oxide production, oxidized LDL and ex vivo susceptibility of LDL to oxidation in mildly hypercholesterolemic otherwise healthy subjects. Plasma ADMA was determined using high performance liquid chromatography tandem mass spectrometry. LDL oxidation was estimated by the lag time and rate of copper-induced LDL oxidation. The nitric oxide production in plasma was estimated based on nitrate (NO(3)(-)) determination and plasma oxidized LDL was determined by a capture ELISA. Low ADMA was a significant determinant for high LDL oxidation rate and concentration of plasma ADMA was associated with nitrate levels. There may be an interplay between LDL fatty acid oxidation rate and plasma ADMA and nitrate. We hypothesize that plasma ADMA has a bivalent role: high ADMA may have a protective role in decelerating LDL fatty acid oxidation and...Continue Reading

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Citations

Nov 8, 2012·Pediatric Transplantation·Irena JankowskaJoanna Pawłowska
Feb 2, 2010·Pediatric Transplantation·Piotr CzubkowskiJoanna Pawlowska
Oct 3, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·Kaire HeilmanVallo Tillmann
Aug 3, 2020·Journal of Pediatric Gastroenterology and Nutrition·Kamil JanowskiPiotr Socha
Oct 24, 2020·Journal of Pediatric Gastroenterology and Nutrition·Kamil JanowskiPiotr Socha

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