Plasma B-type natriuretic peptide concentration is independently associated with kidney function decline in Japanese patients with chronic kidney disease

Journal of Hypertension
Ryota YoshitomiTakanari Kitazono

Abstract

The relationship between B-type natriuretic peptide (BNP) concentration and renal outcomes in patients with chronic kidney disease (CKD) remains unclear; therefore, it has not been determined whether BNP is related to renal outcomes, independent of cardiac parameters. This study was designed to clarify whether BNP concentration is associated with renal outcomes in CKD patients, independent of cardiac functional and structural alterations. This prospective observational study included 372 consecutive patients with CKD. The renal endpoint was the composite of doubling of serum creatinine concentration and end-stage renal disease requiring dialysis. BNP concentrations were divided into quartiles. A Cox proportional hazards model was utilized to determine the risk factors for poor renal outcomes. During a median follow-up of 23.1 months, the renal endpoint was observed in 124 patients, including 14, 18, 37 and 55 patients in the first through fourth BNP quartiles, respectively. After adjustment for covariates, including cardiac parameters such as left atrial diameter, left ventricular mass index, left ventricular ejection fraction, and left ventricular hypertrophy, the hazard ratios (HRs) for renal outcomes became progressively hig...Continue Reading

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Citations

Nov 28, 2018·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Yasuhiro KawaiTakanari Kitazono
Apr 30, 2021·KI Reports·Takaya SasakiToshiharu Ninomiya
Sep 5, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuta MatsukumaTakanari Kitazono

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

JMP10

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